Diagnostic efficacy of optical coherence tomography in the management of preinvasive and invasive cancer of uterine cervix and vulva

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
P F EscobarN Gladkova

Abstract

The purpose of this study was to understand the capabilities and utility of optical coherence tomography (OCT) in characterizing tissue in patients with precancer and cancer of the uterine cervix and vulva. OCT is an optical technique that uses low-coherence interferometer to develop a two-dimensional image of optical scattering from internal tissue microstructure. This study was designed to develop diagnostic criteria. Women undergoing colposcopic evaluation secondary to an abnormal Papanicolaou smear or visualized grossly abnormal vulvar lesion comprised the study population. Under colposcopic visualization, the OCT device was applied to normal regions in all patients and abnormal areas when present, and images were captured. Each subject then underwent multiple directed biopsies. Images were then reviewed and compared with matched histology. A total of 50 women were recruited for the study. Of the 50 patients evaluated, 18 had cervical intraepithelial neoplasia (CIN) II,III, 14 had CIN I, 13 had metaplasia/inflammation, two had invasive squamous cell carcinoma of the cervix, and three had a diagnosis of Paget's disease of the vulva. Analysis of the OCT images showed a repetitive pattern that represented normal squamous epith...Continue Reading

References

Nov 22, 1991·Science·D HuangC A Puliafito
Jun 27, 1997·Science·G J TearneyJ G Fujimoto
Jan 7, 1998·Journal of the American Academy of Dermatology·J WelzelR Engelhardt

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Citations

Jul 30, 2011·Archives of Gynecology and Obstetrics·Irene M OrfanoudakiStavros Sifakis
Mar 22, 2005·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·P F EscobarJ L Belinson
Dec 21, 2011·Sexually Transmitted Diseases·Carmen Radecki BreitkopfSusan L Rosenthal
Oct 3, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·P F EscobarJ L Belinson
Mar 19, 2013·Lasers in Medical Science·R WesselsT J M Ruers
Sep 8, 2007·Journal de gynécologie, obstétrique et biologie de la reproduction·M AscencioS Mordon
Jun 2, 2009·Gynecologic Oncology·Lida P HaririJennifer K Barton
Mar 7, 2009·Current Opinion in Biotechnology·Brett E BoumaGuillermo J Tearney
Feb 27, 2007·Experimental and Molecular Pathology·F M LyngH J Byrne
May 16, 2015·Scientific Reports·Shamira SridharanGabriel Popescu
Dec 17, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·J A LouwersR H M Verheijen
Mar 18, 2011·Lasers in Surgery and Medicine·Julia K S GallwasChristian Dannecker
May 27, 2010·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J GallwasC Dannecker
Jan 17, 2012·Lasers in Surgery and Medicine·Julia GallwasChristian Dannecker
Nov 9, 2004·Academic Radiology·David M ThomassonKing C P Li
Sep 22, 2005·Technology in Cancer Research & Treatment·Wei LuoStephen A Boppart
Dec 3, 2008·Technology in Cancer Research & Treatment·F Bazant-HegemarkN Stone
May 16, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·C-A Y BayanN C Zeitouni
Nov 5, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ronni WesselsTheo J M Ruers
Nov 13, 2007·Journal of Biomedical Optics·Adam M ZyskStephen A Boppart
Nov 22, 2008·Journal of Biomedical Optics·Herculano da Silva MartinhoAirton Abrahão Martin
Apr 9, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Na WulanJerome L Belinson
Feb 6, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Zhihong LiuJerome L Belinson
Jan 18, 2006·Journal of Biomedical Optics·Ilya V TurchinRebecca Richards-Kortum
Jan 13, 2015·Biomedical Optics Express·Tsung-Han TsaiHiroshi Mashimo
Oct 10, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Georgia K ChaselingDaniel Gagnon
Jan 25, 2013·Journal of Lower Genital Tract Disease·Suzanne E BelinsonJerome L Belinson
Jan 1, 2014·Diagnostics·Tsung-Han TsaiHiroshi Mashimo
Apr 30, 2014·Intravital·Hsing-Wen Wang, Yu Chen
Aug 9, 2020·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Jen-Yu WangYu-Hung Wu
Sep 27, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·A Rajabi-EstarabadiK Nouri
Feb 16, 2021·Journal of Lower Genital Tract Disease·Tamera PaczosRachel O'Connell
Jul 30, 2021·Electromagnetic Biology and Medicine·Shadeeb Hossain, Shamera Hossain

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