Diagnostic efficacy of PET/CT plus brain MR imaging for detection of extrathoracic metastases in patients with lung adenocarcinoma.

Journal of Korean Medical Science
Ho Yun LeeHojoong Kim

Abstract

We aimed to evaluate prospectively the efficacy of positron emission tomography (PET)/computed tomography (CT) plus brain magnetic resonance imaging (MRI) for detecting extrathoracic metastases in lung adenocarcinoma. Metastatic evaluations were feasible for 442 consecutive patients (M:F=238:204; mean age, 54 yr) with a lung adenocarcinoma who underwent PET/CT (CT, without IV contrast medium injection) plus contrast-enhanced brain MRI. The presence of metastases in the brain was evaluated by assessing brain MRI or PET/CT, and in other organs by PET/CT. Diagnostic efficacies for metastasis detection with PET/CT plus brain MRI and with PET/CT only were calculated on a per-patient basis and compared from each other. Of 442 patients, 88 (20%, including 50 [11.3%] with brain metastasis) had metastasis. Regarding sensitivity of overall extrathoracic metastasis detection, a significant difference was found between PET/CT and PET/CT plus brain MRI (68% vs. 84%; P=0.03). As for brain metastasis detection sensitivity, brain MRI was significantly higher than PET/CT (88% vs. 24%; P<0.001). By adding MRI to PET/CT, brain metastases were detected in additional 32 (7% of 442 patients) patients. In lung adenocarcinoma patients, significant inc...Continue Reading

References

Jan 1, 1992·CA: a Cancer Journal for Clinicians·C C BoringT Tong
Sep 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J B SørensenP Dombernowsky
Jul 1, 1995·American Journal of Respiratory and Critical Care Medicine·G A SilvestriG L Colice
Sep 9, 1999·Radiology·E M MaromE F Patz
Mar 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T J RobnettS M Hahn
Jan 30, 2002·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael Thun
Jun 12, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Angelika ZabelJürgen Debus
Mar 3, 2007·The European Respiratory Journal·W De WeverJ Verschakelen
Aug 31, 2007·Journal of Magnetic Resonance Imaging : JMRI·Yoshiharu OhnoKazuro Sugimura
Oct 6, 2007·Chest·Gerard A SilvestriUNKNOWN American College of Chest Physicians
Feb 28, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Amarnath JenaJai Bhagwan Sharma

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Citations

Jul 24, 2010·Der Radiologe·C KratochwilF L Giesel
Jun 9, 2015·PET Clinics·Mie Holm Vilstrup, Drew A Torigian
Dec 17, 2014·Seminars in Roentgenology·Li FanPrabhakar Rajiah
Jun 24, 2011·The British Journal of Radiology·B HochheggerH-U Kauczor
Jul 5, 2011·Revista española de medicina nuclear e imagen molecular·A Palomar MuñozA Soriano Castrejón
Jun 9, 2015·Seminars in Nuclear Medicine·Paul FlechsigFrederik L Giesel
Sep 23, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Emma L O'DowdDavid R Baldwin
Aug 11, 2018·The European Respiratory Journal·Ivan VollmerRamón Rami-Porta
Jun 7, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M MajemM Provencio
Apr 3, 2020·The Journal of Laryngology and Otology·H MerchantJ A Smith
Jul 14, 2010·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Bruno HochheggerEdson Marchiori
Aug 25, 2015·Nuclear Medicine Communications·Karin HjorthaugPer Borghammer
Oct 17, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Martin W HuellnerPatrick Veit-Haibach

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BETA
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Xeleris

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