PMID: 9420817Sep 1, 1995Paper

Diagnostic efficacy of stress technetium 99m-labeled sestamibi myocardial perfusion single-photon emission computed tomography in detection of coronary artery disease among patients over age 80

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
F P WangD S Berman

Abstract

Because symptoms of myocardial ischemia in elderly patients are often atypical, accurate noninvasive assessment of the presence, extent, and severity of coronary artery disease (CAD) would be especially useful to avoid unnecessary catheterization or invasive intervention. This study assessed the safety and diagnostic efficacy of 99mTc-labeled sestamibi (99mTc-sestamibi) exercise and pharmacologic myocardial perfusion single-photon emission computed tomography (SPECT) with adenosine or dipyridamole in patients age 80 years or older. Stress 99mTc-sestamibi SPECT was performed in 75 consecutive patients who were 80 years old or older (range: 80 to 91 years) with suspected CAD and who underwent coronary angiography within 6 months of the nuclear study. Of these patients, 51 underwent a pharmacologic (adenosine = 42; dipyridamole = 9) stress study and 24 underwent an exercise treadmill study. A normalcy rate was derived from an additional 36 patients (ages 83 +/- 3 years) who had undergone stress 99mTc-sestamibi SPECT and who had a relatively low likelihood (< 20%) of CAD. No serious adverse events occurred during or after the exercise or the pharmacologic stress test. The overall sensitivity and specificity for detecting CAD with >...Continue Reading

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Citations

Jun 16, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Luca Nai FovinoLaura Evangelista
Dec 25, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Pasquale Perrone-FilardiMassimo Chiariello
Nov 3, 2007·The American Journal of Geriatric Cardiology·Todd D Miller, Marcelo F DiCarli
Jul 7, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Stefan RoestArend F L Schinkel
Dec 28, 2002·The American Journal of Geriatric Cardiology·K E Fleischmann
Aug 20, 2009·Angiology·Manavjot SidhuThomas Dresser
Oct 28, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Masaki KawamuraShigeyuki Nishimura
May 20, 2006·Nuclear Medicine Communications·Olivier De WinterJohan De Sutter
May 29, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Kunihiko HatanakaTohru Ohe
Sep 26, 2020·Journal of the American College of Cardiology·Daniel E FormanUNKNOWN Geriatric Cardiology Section Leadership Council

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