Diagnostic efficiency of toluidine blue with Lugol's iodine in oral premalignant and malignant lesions

Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research
Kamarthi NagarajuL Ashok

Abstract

In vivo stains are prompt resources, which have emerged, in the recent years, to aid as clinical diagnostic tools in detecting early premalignant and malignant lesions. The aim of the study was to determine the diagnostic efficiency of toluidine blue with Lugol's iodine in oral premalignancies and malignancies and to evaluate the reliability of in vivo staining with toluidine blue and Lugol's iodine in the lesions at risk of malignancy. The study group comprised 30 subjects with clinically suspicious premalignant lesions and 30 subjects with clinically suspicious malignant lesions. All the lesions were stained consecutively with toluidine blue and Lugol's iodine and the dye retention were recorded with photographs. Depending on the retention of the dyes, the biopsy site was determined. The biopsy specimens were sent for histological confirmation and results were statistically analyzed. The overall diagnostic accuracy of Lugol's iodine when used consecutively with toluidine blue stain in distinguishing premalignant lesions and malignant lesions was 90%. As the degree of differentiation of malignant lesions progressed toward more severity, they failed to show the retention of Lugol's iodine and the result was highly significant s...Continue Reading

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Citations

Feb 19, 2016·The Tohoku Journal of Experimental Medicine·Dongjuan LiuQianming Chen
Dec 4, 2012·The Journal of the American Dental Association·Joel B EpsteinElliot Abt
Jan 27, 2015·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Deepti Singh, R K Shukla
May 30, 2015·The Cochrane Database of Systematic Reviews·Richard MaceyCrispian Scully
Aug 16, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Suzan Seif IbrahimMona Hassan Hassan
Nov 20, 2019·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Vidhu VijayakumarAswin Mukundan
Jul 21, 2021·The Cochrane Database of Systematic Reviews·Tanya WalshSaman Warnakulasuriya

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