Diagnostic errors in the new millennium: a follow-up autopsy study

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Stefanie Schwanda-BurgerFranco Salomon

Abstract

A systematic review of the second half of the last century suggested that diagnostic errors have decreased over time. Our previous study covering the years 1972-1992 was then the only time series showing a significant reduction of diagnostic errors from a single institution. We report here the results of a follow-up study a decade later. We analyzed discrepancies between clinical and autoptic diagnoses in 100 randomly selected medical patients who died in the wards and in the medical intensive care unit at a tertiary-care teaching hospital in Switzerland in the year 2002. Autopsy rate declined from around 90% in the years from 1972 to 1992 to 54% in the present study. Major diagnostic errors (class I and II) declined significantly from 30 to 7% (P<0.001) over the last 30 years. Class I errors decreased from 16 to 2% (P<0.001) in the year 2002. Sensitivity for cardiovascular diseases increased from 69 to 92% (P=0.006), for infectious diseases from 25 to 90% (P=0.013) and for neoplastic diseases from 89 to 100% (P=0.053). Specificity for cardiovascular diseases increased from 85 to 98% (P<0.001) but was unchanged at a high level for infectious diseases and neoplastic diseases. The number of diagnostic procedures increased from 14...Continue Reading

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