Diagnostic evaluation and monitoring of patients with posterior cortical atrophy

Neurodegenerative Disease Management
Bonnie WongBradford C Dickerson

Abstract

Posterior cortical atrophy (PCA) is a progressive neurocognitive syndrome, most commonly associated with the loss of complex visuospatial functions. Diagnosis is challenging, and international consensus classification and nomenclature for PCA subtypes have only recently been reached. Presently, no established treatments exist. Efforts to develop treatments are hampered by the lack of standardized methods to monitor illness progression. Although measures developed from work with Alzheimer's disease and other dementias provide a foundation for diagnosing and monitoring progression, PCA presents unique challenges for clinicians counseling patients and families on clinical status and prognosis, and experts designing clinical trials of interventions. Here, we review issues facing PCA clinical research and care, summarize our approach to diagnosis and monitoring of disease progression, and outline ideas for developing tools for these purposes.

References

Apr 1, 1991·Brain : a Journal of Neurology·T Shallice, P W Burgess
Jul 1, 1988·Archives of Neurology·D F BensonB D Snyder
Dec 1, 1986·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·M Jackson, E K Warrington
May 1, 1982·Journal of Gerontology·R I PfefferS Filos
Jan 1, 1982·Journal of Psychiatric Research·J A YesavageV O Leirer
Nov 15, 1993·Annals of Internal Medicine·B N JonesK S Harrison
Sep 23, 2000·The Journal of Neuropsychiatry and Clinical Neurosciences·D I KauferS T DeKosky
Feb 7, 2001·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·A P PorsteinssonC Irvine
Jun 8, 2002·Dementia and Geriatric Cognitive Disorders·Mario F MendezKent M Perryman
Sep 24, 2002·JAMA : the Journal of the American Medical Association·Constantine G LyketsosSteven DeKosky
Apr 2, 2003·Journal of the International Neuropsychological Society : JINS·Marla J Hamberger, William T Seidel
Jan 1, 1996·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·D A CahnE Barrett-Connor
Apr 9, 2005·Journal of the American Geriatrics Society·Ziad S NasreddineHoward Chertkow
Aug 9, 2005·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·A EibensteinM Fusetti
Oct 20, 2005·JAMA : the Journal of the American Medical Association·Lon S SchneiderPhilip Insel
Feb 16, 2006·Neurology·Paul McMonagleAndrew Kertesz
May 2, 2006·The American Journal of Psychiatry·Robert Christian Wolf, Carlos Schönfeldt-Lecuona
Oct 13, 2006·Archives of Neurology·Keith A JosephsRonald C Petersen
Apr 5, 2007·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Mario F MendezDavid G Clark
Sep 28, 2007·Brain : a Journal of Neurology·S AlladiJ R Hodges
Oct 19, 2007·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Julie S SnowdenDavid Mann
Jun 26, 2008·Journal of the International Neuropsychological Society : JINS·Jacobus Donders, Kelly Janke
Jul 2, 2008·Neuropsychology·Sarah Tomaszewski FariasCharles Decarli
Sep 23, 2008·The Journal of Neuropsychiatry and Clinical Neurosciences·John J Campbell, Gilda Ngo
Mar 20, 2009·Annals of Neurology·Leslie M ShawUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Nov 12, 2009·Brain : a Journal of Neurology·Elena RusconiAndreas Kleinschmidt
Apr 12, 2011·Brain : a Journal of Neurology·Aurélie KasMarie Sarazin
Jun 1, 2011·Arquivos de neuro-psiquiatria·Leonardo Caixeta
Oct 1, 2011·Alzheimer Disease and Associated Disorders·Raphaël DepazJean Philippe Brandel
Oct 27, 2011·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·Lori LettsColleen O'Toole
Oct 27, 2011·Neurocase·Jonathan KennedySebastian J Crutch
Jan 24, 2012·Lancet Neurology·Sebastian J CrutchNick C Fox
Mar 1, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Manja LehmannNick C Fox
Nov 10, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Sebastian J CrutchJonathan D Rohrer
Jan 1, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Sebastian J CrutchNick C Fox
Feb 5, 2013·Applied Neuropsychology. Adult·D Erik EverhartC Ervin Davis
Apr 25, 2013·International Review of Psychiatry·Mary Anne WylieEdward D Huey
Jul 3, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Keith A JohnsonUNKNOWN Amyloid Imaging Task Force of the Alzheimer’s Association and Society for Nuclear Medicine and Molecular Imaging
Oct 5, 2013·European Radiology·Christiane MöllerHugo Vrenken

❮ Previous
Next ❯

Methods Mentioned

BETA
PCA

Software Mentioned

PCA
plus

Related Concepts

Related Feeds

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Alzheimer's Disease: Genetics

Alzheimer's disease is a neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations with this feed.