Diagnostic evaluation of a deep learning model for optical diagnosis of colorectal cancer.

Nature Communications
Dejun ZhouXiangchun Li

Abstract

Colonoscopy is commonly used to screen for colorectal cancer (CRC). We develop a deep learning model called CRCNet for optical diagnosis of CRC by training on 464,105 images from 12,179 patients and test its performance on 2263 patients from three independent datasets. At the patient-level, CRCNet achieves an area under the precision-recall curve (AUPRC) of 0.882 (95% CI: 0.828-0.931), 0.874 (0.820-0.926) and 0.867 (0.795-0.923). CRCNet exceeds average endoscopists performance on recall rate across two test sets (91.3% versus 83.8%; two-sided t-test, p < 0.001 and 96.5% versus 90.3%; p = 0.006) and precision for one test set (93.7% versus 83.8%; p = 0.02), while obtains comparable recall rate on one test set and precision on the other two. At the image-level, CRCNet achieves an AUPRC of 0.990 (0.987-0.993), 0.991 (0.987-0.995), and 0.997 (0.995-0.999). Our study warrants further investigation of CRCNet by prospective clinical trials.

References

Nov 3, 2006·The New England Journal of Medicine·Jaroslaw RegulaEugeniusz Butruk
May 1, 2010·Lancet·Wendy S AtkinUNKNOWN UK Flexible Sigmoidoscopy Trial Investigators
Jul 6, 2010·Gastroenterology·Harminder SinghCharles N Bernstein
May 23, 2012·The New England Journal of Medicine·Robert E SchoenUNKNOWN PLCO Project Team
Jun 16, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelElizabeth Ward
Nov 21, 2015·Gastrointestinal Endoscopy·Benjamin L BickDouglas K Rex
Oct 19, 2017·Gastroenterology·Peng-Jen ChenVincent S Tseng
Apr 14, 2018·Gastroenterology·Masashi MisawaKensaku Mori
Dec 12, 2018·The Lancet. Gastroenterology & Hepatology·Omer F AhmadLaurence B Lovat

❮ Previous
Next ❯

Citations

Sep 17, 2020·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Kazuki SumiyamaNaoto Tamai
May 1, 2021·Cancer Cell·Benjamin H KannHugo J W L Aerts
May 11, 2021·World Journal of Gastroenterology : WJG·Jia-Sheng CaoXiu-Jun Cai
Jul 4, 2021·Gastrointestinal Endoscopy·Dan M LivovskyDaniel Freedman

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
surgical
dissection
imaging technique
surgical resection

Software Mentioned

R package irr
CAM
HuPAS
R package pROC
CRCNet
AlexNet
R
Python
Grad
PyTorch

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.