Diagnostic evaluation of food-related allergic diseases.

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
John EckmanRobert G Hamilton

Abstract

Food allergy is a serious and potentially life-threatening problem for an estimated 6% of children and 3.7% of adults. This review examines the diagnostic process that begins with a patient's history and physical examination. If the suspicion of IgE-mediated food allergy is compelling based on the history, skin and serology tests are routinely performed to provide confirmation for the presence of food-specific IgE antibody. In selected cases, a provocation challenge may be required as a definitive or gold standard reference test for confirmation of IgE mediated reactions to food. Variables that influence the accuracy of each of the diagnostic algorithm phases are discussed. The clinical significance of food allergen-specific IgE antibody cross-reactivity and IgE antibody epitope mapping of food allergens is overviewed. The advantages and limitations of the various diagnostic procedures are examined with an emphasis on future trends in technology and reagents.

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Citations

Aug 2, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Robert G HamiltonRobert A Wood
May 11, 2010·The Journal of Allergy and Clinical Immunology·Robert G HamiltonUNKNOWN American College of Allergy, Asthma and Immunology
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Jul 12, 2017·Journal of Immunoassay & Immunochemistry·René Rübenhagen, Marc Dangers
Mar 17, 2012·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Amber Moore, Kylie O'Brien
Jun 17, 2015·Journal of Wound Care·Keith Cutting, James McGuire

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Methods Mentioned

BETA
chip
antibody
antibody assay

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