Diagnostic exercise. Cerebral mass in a puppy with respiratory distress and progressive neurologic signs

Veterinary Pathology
L T ReedR A Packer

Abstract

A 5-month-old mongrel puppy with a history of respiratory disease presented with progressive neurologic dysfunction. Hematologic results included leukocytosis (neutrophilia with a left shift) and lymphopenia. A mass in the right forebrain, identified by magnetic resonance imaging, was biopsied during decompressive craniectomy. The histologic diagnosis was granulomatous meningoencephalitis with intralesional amoebae. The dog died within 24 hours of surgery. At necropsy, a well-demarcated granuloma was confined to the cerebrum, but granulomatous pneumonia was disseminated through all lobes of the lung. Concurrent infections included canine distemper, canine adenoviral bronchiolitis, and oral candidiasis. Canine distemper virus probably caused immunosuppression and increased susceptibility to secondary infections.

References

Mar 1, 1991·Reviews of Infectious Diseases·G S Visvesvara
Jul 1, 1993·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·R W BauerW L Chapman
Mar 3, 2005·Veterinary Parasitology·J P DubeyG S Visvesvara
Apr 27, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Hailu KindeGovinda S Visvesvara
Nov 21, 2008·Veterinary Immunology and Immunopathology·A BeinekeW Baumgärtner

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Citations

Feb 27, 2015·Archives of Microbiology·María ValladaresJacob Lorenzo-Morales
Sep 7, 2014·Veterinary Parasitology·María ValladaresJacob Lorenzo-Morales
Mar 17, 2020·Journal of the American Veterinary Medical Association·Rod B SuepaulJoy Gary
Sep 27, 2019·Frontiers in Veterinary Science·Lauren DiangeloR Timothy Bentley

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Methods Mentioned

BETA
biopsy
PCR

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