Diagnostic findings in 95 Finnish patients with common variable immunodeficiency

Journal of Clinical Immunology
Leena KainulainenOlli Ruuskanen

Abstract

Common variable immunodeficiency is the most frequent of the primary hypogammaglobulinemias. It is manifested by a wide variety of clinical signs and symptoms. In this retrospective, nationwide survey data were collected on all patients with common variable immunodeficiency who were receiving immunoglobulin replacement therapy in Finland to study the prediagnostic clinical picture, diagnostic delay, and diagnostic findings. Ninety-five patients were identified. The median age of the patients was 33 years. Sixteen of the patients were children. Sinopulmonary infections were the most common prediagnostic signs and symptoms; 66% had suffered from recurrent pneumonia, 60% from recurrent maxillary sinusitis, and 45% from recurrent bronchitis. There was a considerable delay in diagnosis. The mean delay was 8 years. At the time of diagnosis chronic pulmonary complications had already developed in 17% of the patients. The diagnosis was based on low serum immunoglobulin concentrations. This study showed that the awareness of common variable immunodeficiency is low. To improve the recognition of hypogammaglobulinemia, it should be suspected in every patient with recurrent bacterial infections. In addition to a low serum IgG concentration...Continue Reading

Citations

Nov 24, 2004·Anais Da Academia Brasileira De Ciências·Cristina M KokronLuiz V Rizzo
Mar 9, 2006·Clinical and Vaccine Immunology : CVI·Hale YarmohammadiCharlotte Cunningham-Rundles
Feb 22, 2007·European Journal of Clinical Nutrition·J BierwirthT Witte
Jan 7, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Asghar AghamohammadiNima Rezaei
Jan 26, 2010·Clinical Medicine : Journal of the Royal College of Physicians of London·Philip Wood, UNKNOWN UK Primary Immunodeficiency Network
Apr 6, 2012·Immunologic Research·Charlotte Cunningham-Rundles
Oct 3, 2012·Current Opinion in Allergy and Clinical Immunology·Elena S Resnick, Charlotte Cunningham-Rundles
Mar 1, 2012·Annals of the New York Academy of Sciences·Paolo Ruggero ErranteAntonio Condino-Neto
Oct 17, 2013·Expert Review of Clinical Immunology·Yashwant Kumar, Alka Bhatia
Dec 20, 2018·Immunological Reviews·Charlotte Cunningham-Rundles
Sep 1, 2005·Journal of Clinical Immunology·Davood MansouriStuart E Turvey
Oct 6, 2007·Immunologic Research·Charlotte Cunningham-Rundles, Adina Kay Knight
Apr 14, 2007·Digestive Diseases and Sciences·Ahmad KhodadadNasser Ebrahimi Daryani
Jul 15, 2009·Clinical Microbiology Reviews·Ari J Fried, Francisco A Bonilla
Mar 25, 2010·Blood·Charlotte Cunningham-Rundles
Dec 20, 2011·Blood·Elena S ResnickCharlotte Cunningham-Rundles
Jan 1, 2012·Case Reports in Nephrology·Ali Kemal KadiroğluM Emin Yılmaz
Oct 17, 2017·Frontiers in Immunology·Jannica S SeleniusMikko Seppänen
Sep 24, 2005·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Beatriz T Costa CarvalhoDirceu Solé
Jan 13, 2012·Annals of the New York Academy of Sciences·Joon H ParkCharlotte Cunningham-Rundles
Jul 29, 2020·International Journal of Molecular Sciences·Ida Judyta MaleszaPiotr Eder
Jun 15, 2007·Clinical and Experimental Immunology·P WoodUNKNOWN UK Primary Immunodeficiency Network
Apr 7, 2009·British Journal of Haematology·Helen Chapel, Charlotte Cunningham-Rundles
Sep 28, 2010·Journal of Pediatric Gastroenterology and Nutrition·Anthony L GuerrerioMaria Oliva-Hemker
Jun 22, 2002·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Zuzana KrátkáTereza Fucíková
Mar 23, 2015·Allergologia et immunopathologia·E O DantasB T Costa Carvalho
Jul 15, 2021·Seminars in Respiratory and Critical Care Medicine·Pamela J McShane
Oct 3, 2021·Journal of Clinical Immunology·Cornelia M van SchewickBodo Grimbacher

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Related Papers

The Journal of Allergy and Clinical Immunology
Leena KainulainenOlli Ruuskanen
Archives of Otolaryngology--head & Neck Surgery
Leena KainulainenOlli Ruuskanen
Pneumonologia i alergologia polska
Katarzyna ModrzewskaKazimierz Roszkowski-Sliz
© 2021 Meta ULC. All rights reserved