Diagnostic guidelines for the histological particle algorithm in the periprosthetic neo-synovial tissue

BMC Clinical Pathology
G PerinoV Krenn

Abstract

The identification of implant wear particles and non-implant related particles and the characterization of the inflammatory responses in the periprosthetic neo-synovial membrane, bone, and the synovial-like interface membrane (SLIM) play an important role for the evaluation of clinical outcome, correlation with radiological and implant retrieval studies, and understanding of the biological pathways contributing to implant failures in joint arthroplasty. The purpose of this study is to present a comprehensive histological particle algorithm (HPA) as a practical guide to particle identification at routine light microscopy examination. The cases used for particle analysis were selected retrospectively from the archives of two institutions and were representative of the implant wear and non-implant related particle spectrum. All particle categories were described according to their size, shape, colour and properties observed at light microscopy, under polarized light, and after histochemical stains when necessary. A unified range of particle size, defined as a measure of length only, is proposed for the wear particles with five classes for polyethylene (PE) particles and four classes for conventional and corrosion metallic particle...Continue Reading

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Citations

Sep 8, 2019·Journal of Materials Science. Materials in Medicine·I Papadimitriou-OlivgeriN A Athanasou
Dec 13, 2019·Frontiers in Immunology·Janosch SchoonAnastasia Rakow
Oct 27, 2020·Advanced Science·Janosch SchoonSven Geissler

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Methods Mentioned

BETA
light microscopy
total hip arthroplasty
for transmission electron
total ankle arthroplasty
electron microscopy
scanning
x-ray fluorescence spectroscopy
X-ray
biopsies

Software Mentioned

SLIM
MoM
Leica DM

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