Diagnostic impact of core-needle biopsy on fine-needle aspiration of non-Hodgkin lymphoma

Diagnostic Cytopathology
Jerald Z GongClaudia K Jones

Abstract

We retrospectively reviewed 74 fine-needle aspiration (FNA) cases of presumptive non-Hodgkin lymphoma (NHL). All the cases had cytology and core-needle biopsy and 53 cases had concurrent flow cytometric analysis. FNA (cytology and flow cytometry) and core-needle biopsy were evaluated independently. FNA was diagnostic of diffuse large B-cell lymphoma (DLBL) in 25% (13/53) of cases and small B-cell NHL in 15% (8/53) of cases, whereas core-needle biopsy was diagnostic of DLBL in 37% (27/74) of cases and small B-cell NHL in 8% (6/74) of cases. Subclassification of small B-cell NHL was reached in 3/6 cases by core-needle biopsy. Insufficient cases were observed in both FNA (47%; 25/53) and core-needle biopsy (28%; 21/74) groups. With the combination of FNA and core-needle biopsy, diagnostic cases of DLBL increased to 43% (32/74) and insufficient samples were reduced to 16% (12/74). There was no clear advantage in the diagnosis and classification of small B-cell NHL by adding core-needle biopsy to FNA (14%; 10/74). We conclude that core-needle biopsy is a useful adjunct to FNA in the diagnosis of DLBL and shall be encouraged. In small B-cell NHL, core-needle biopsy does not add to the diagnostic ability of FNA. Cases insufficient for...Continue Reading

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Citations

May 27, 2005·Journal of Clinical Pathology·G Kocjan
Jun 14, 2012·Pathology Research International·Joerg Schwock, William R Geddie
Aug 24, 2013·Radiology·Regina J HooleyLiane E Philpotts
May 22, 2009·Cytopathology : Official Journal of the British Society for Clinical Cytology·H GerkeC S Jensen
Jan 23, 2015·Archives of Pathology & Laboratory Medicine·John K FrederiksenW Richard Burack
Feb 3, 2016·European Journal of Haematology·Laura GroneckMartin R Weihrauch
Aug 2, 2013·Therapeutic Advances in Musculoskeletal Disease·Inge A M van den OeverMichael T Nurmohamed
Mar 4, 2017·JMIR Research Protocols·Carolin BernerThomas Ernst Dorner
Apr 5, 2021·Journal of the American Society of Cytopathology : JASC·Ahmed ShahMonalisa Sur
Jul 10, 2007·Archives of Pathology & Laboratory Medicine·Whitney A LacharA Joe Saad

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