Abstract
Histopathological differentiation between hepatocellular adenoma and well differentiated hepatocellular carcinoma (HCC) may be a difficult task in small biopsies and occasionally in resected tumor specimens. Whether the analysis of chromosome aberrations can contribute to a more precise discrimination has not been analyzed systematically up to now. Therefore, fluorescence in situ hybridization was applied to 28 cases of adenoma and well differentiated carcinoma, using centromeric probes for chromosomes 1, 6, 7, 8, and X. None of 14 adenomas revealed an aberrant count in the analyses performed. By contrast, 13/14 carcinomas demonstrated aberrations for 2-5 chromosomes/case. Chromosome 1 was aberrant in 8/12 cases informative for this probe (67%), chromosomes 6 and 7 were aberrant in 9/14 cases (64%), chromosome 8 was aberrant in 11/14 cases (79%), and chromosome X in 7/14 cases (50%). Taking results for chromosomes 1 and 8 together, 13/14 HCC revealed aberrations for at least one of these chromosomes. Probes for 6, 7, and X revealed no additional aberrant cases.Thus, FISH for chromosomes 1 and 8, extended by probes for chromosomes 6, 7 and X, represents a promising approach toward a more accurate differentiation between hepatoce...Continue Reading
References
Feb 1, 1992·Cancer Genetics and Cytogenetics·G BardiF Mitelman
Oct 30, 1992·Science·A KallioniemiD Pinkel
Sep 1, 1989·Cancer·H SaitoM Tsuchiya
Jan 1, 1985·Journal of Hepatology·D CarrascoJ Berenguer
Feb 1, 1996·Cancer Genetics and Cytogenetics·H L ChenD S Chen
Jan 1, 1997·Genes, Chromosomes & Cancer·A MarchioA Dejean
Apr 1, 1997·Nature Genetics·F MitelmanB Johansson
Jan 1, 1999·Nature·C LengauerB Vogelstein
Jan 23, 1999·The American Journal of Pathology·N WongP J Johnson
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D B ZimonjicN C Popescu
May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N KusanoK Sasaki
Mar 29, 2001·The Journal of Pathology·L WilkensH H Kreipe
Citations
Jun 1, 2006·Der Pathologe·P FlemmingL Wilkens
Jun 11, 2005·Virchows Archiv : an International Journal of Pathology·Ludwig WilkensBrigitte Schlegelberger
Jul 10, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Siong-Seng LiauEmmanuel Huguet
Jan 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ludwig WilkensBrigitte Schlegelberger
Aug 13, 2008·Annals of Surgical Oncology·Sung W ChoT Clark Gamblin
Oct 30, 2010·Indian Journal of Human Genetics·Magdy S AlyZekri N Abdel-Rahman
Apr 20, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sanjay KakarLinda D Ferrell
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Ludger Barthelmes, Iain S Tait
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Kenneth A LarsonLeslie H Blumgart
Nov 13, 2007·Journal of Hepatology·Sandra RebouissouJessica Zucman-Rossi
Jan 24, 2007·Journal of Hepatology·P Bioulac-SageUNKNOWN Laennec and Elves groups
Jun 10, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Shefali AgrawalJacques Belghiti
Sep 19, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Doris SteinemannLudwig Wilkens
Aug 22, 2009·Histopathology·Sanjay KakarLinda D Ferrell
Apr 22, 2014·Human Pathology·Nafis ShafizadehSanjay Kakar
May 26, 2006·Histopathology·L WilkensP Flemming
Aug 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ruben R PlentzLudwig Wilkens
Sep 30, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Britta SkawranLudwig Wilkens
Aug 24, 2004·Advances in Anatomic Pathology·Vijay Varma, Cynthia Cohen
Sep 26, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ya-Wen ChenPei-Jer Chen
Oct 14, 2011·Advances in Anatomic Pathology·Nafis Shafizadeh, Sanjay Kakar
Nov 11, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sanjay KakarLinda D Ferrell
Apr 16, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ludwig WilkensPeer Flemming
Dec 6, 2005·The American Journal of Surgical Pathology·Zong-Ming E ChenHanlin L Wang
Jun 20, 2006·Scandinavian Journal of Gastroenterology. Supplement·Türkan TerkivatanJan N M Ijzermans
Oct 17, 2003·World Journal of Gastroenterology : WJG·Masahiro ItoMasamichi Kojiro
Jun 26, 2020·Virchows Archiv : an International Journal of Pathology·Andrea JonesRoger K Moreira
Nov 12, 2015·World Journal of Hepatology·Adarsh VijayHatem Khalaf