Diagnostic impact of the genetic variability of the hepatitis B virus surface antigen gene

Journal of Medical Virology
B Weber

Abstract

The genetic variability of hepatitis B virus (HBV) represents a challenge for the sensitivity of immunologic and molecular based assays. Genotyping studies show that the genetic diversity of HBV is very high even in industrialized countries. The analytical sensitivity of HBsAg and anti-HBs assays may be dependent on HBV genotype or subtype and could possibly lead to false negative results in samples with low-level HBsAg. It is possible that the recognition of genotypes E and F may be impaired. Immunoassays based on polyclonal capture antibody show the highest sensitivity for the recognition of recombinant mutants or serum samples harboring mutant forms of HBsAg. However, they do not guarantee full sensitivity, especially for the detection of the G145R mutation and amino acid insertions or substitutions in positions 120-123. Detection of HBsAg needs to be improved by the introduction of new HBsAg assays able to recognize so far described S gene mutants and with a lower detection threshold than current immunoassays in order to detect smallest amounts of HBsAg in low level carriers. There is also a need for more complete epidemiological data on the prevalence of HBsAg mutants especially for G145R and assays for the (differential) ...Continue Reading

References

Aug 11, 1990·Lancet·W F CarmanH C Thomas
Jan 1, 1997·Journal of Viral Hepatitis·W F Carman
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M FriedtS Wirth
Jun 29, 1999·Advances in Virus Research·S GüntherH Will
Jul 16, 1999·Journal of Clinical Microbiology·B WeberW Melchior
Aug 10, 1999·Journal of Medical Virology·P F ColemanI K Mushahwar
Oct 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M P CooremanW P Paulij
May 5, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J H IrelandW F Carman
Aug 22, 2000·The Journal of General Virology·C HannounM Lindh
Jun 26, 2001·Journal of Medical Virology·B WeberH Rabenau
Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J H KaoD S Chen
Mar 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hideaki KatoMasashi Mizokami
May 25, 2002·The Journal of General Virology·Karin Kidd-LjunggrenAlistair H Kidd
Aug 29, 2002·The Journal of Infectious Diseases·Charles HannounUNKNOWN Interpred trial group
Jun 28, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Fadel AlhababiC Y William Tong
Jan 13, 2004·Reviews in Medical Virology·Angeline Bartholomeusz, Stephan Schaefer
Jun 25, 2004·The Journal of Infectious Diseases·Mick N MuldersClaude P Muller
Jan 18, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Bernard Weber
Mar 9, 2005·Vaccine·Anna KramvisGuido François
Jun 17, 2005·The Journal of General Virology·Fuat KurbanovMasashi Mizokami

❮ Previous
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Citations

Sep 8, 2010·Archives of Virology·Jianjun NiuNingshao Xia
Jun 8, 2007·Journal of Translational Medicine·Florian BihlChristian Brander
Apr 17, 2012·Virology Journal·Yang Yong-LinCai Xu-Bing
Apr 8, 2011·World Journal of Gastroenterology : WJG·Sara OcanaJose Luis Lledo
Oct 28, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Mahmoud Reza PourkarimMarc Van Ranst
Aug 19, 2015·Diagnostic Microbiology and Infectious Disease·Anders BoydKarine Lacombe
Dec 19, 2014·Journal of Medical Virology·Erica DarmawanDavid Handojo Muljono
Oct 24, 2013·Journal of Medical Virology·Mahmoud Reza PourkarimMarc Van Ranst
Jan 21, 2014·Journal of Viral Hepatitis·X Huang, F B Hollinger
Dec 17, 2009·Journal of Viral Hepatitis·F B Hollinger, G Sood
Nov 28, 2012·Journal of Hepatology·Julie BotteroKarine Lacombe
Aug 22, 2008·Journal of Hepatology·Giovanni RaimondoFabien Zoulim
Jul 9, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·M ChudyW H Gerlich
Jul 14, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Seyed Moayed AlavianSeyed Mohammad Jazayeri
Jul 29, 2016·Journal of Medical Virology·Massimo De PaschalePierangelo Clerici
Mar 1, 2012·Revista Da Sociedade Brasileira De Medicina Tropical·Adila Liliane Barros DiasWornei Silva Miranda Braga
Apr 20, 2006·Journal of Medical Virology·Gerald Schochetman, Mary C Kuhns
May 7, 2008·The Korean journal of laboratory medicine·Sang Hyun HwangHan Chul Son
Dec 25, 2007·The Korean journal of laboratory medicine·Sang Hyun HwangEun Yup Lee
Jan 3, 2009·The Korean Journal of Hepatology·Hyung Joon Yim
Jul 16, 2015·Archives of Virology·Nadia Hadiji-AbbesRaja Mokdad-Gargouri
Apr 8, 2016·World Journal of Gastroenterology : WJG·Hui-Lan ZhuZhen-Hua Zhang
Jun 6, 2017·PloS One·Barbara J HarrisCatherine A Brennan
Dec 30, 2014·World Journal of Hepatology·Min-Sun Kwak, Yoon Jun Kim

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