PMID: 2510497Nov 1, 1989Paper

Diagnostic limitations of spontaneous growth hormone measurements in normally growing prepubertal children

American Journal of Diseases of Children
R Lanes

Abstract

To evaluate whether the measurement of the spontaneous overnight growth hormone secretion in prepubertal children clearly separated normal children from subjects with growth hormone deficiency, we studied 45 prepubertal normally growing children (10 with normal height and 35 with constitutional growth delay) and compared their overnight growth hormone secretion with that of a group of subjects with either isolated growth hormone deficiency or neurosecretory dysfunction. Peak growth hormone levels (greater than or equal to 10 ng/mL) following oral clonidine administration were normal in individuals with normal height, constitutional growth delay, and neurosecretory dysfunction, as was the basal somatomedin C concentration; subjects with growth hormone deficiency had low peak growth hormone levels (less than 10 ng/mL) following oral clonidine administration as well as low basal somatomedin C values. The mean 9-hour overnight growth hormone concentration, total growth hormone output, total number of nocturnal pulses, and the mean peak growth hormone response during nocturnal sampling were similar in the normal height and constitutional growth delay groups and significantly greater than those seen in subjects with either growth hor...Continue Reading

Citations

Jan 30, 2004·Journal of Clinical Pathology·R Ayling
Aug 1, 1994·European Journal of Pediatrics·G SaggeseG Perri
Oct 1, 1992·Current Problems in Pediatrics·J A Grunt, I D Schwartz
May 26, 2004·Clinics in Laboratory Medicine·Raj Pandian, Jon M Nakamoto
Dec 12, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·P C SizonenkoZ Laron
Jun 1, 1991·Clinical Endocrinology·S SainiC G Brook
Apr 11, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Camilia KamounAdda Grimberg

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