Diagnostic lipid changes in patients with visceral leishmaniasis

Hospital Practice
Vasilis TsimihodimosMoses Elisaf

Abstract

Visceral leishmaniasis (VL) has been associated with the increase in triglyceride (TG) levels and the decrease in high-density lipoprotein cholesterol (HDL-C) concentration. The aim of the study was to evaluate whether there is a diagnostic cut-off point in these lipid profile changes. We included 100 patients with febrile infections. Analytically, 22 patients with VL, 18 patients with leptospirosis, 20 patients with Brucella melitensis, and 40 age- and sex-matched patients with fever and proven bacteremia (endocarditis and pyelonephritis). The lipid parameters were assessed for their diagnostic accuracy using logistic regression and receiver operating characteristic statistics. It was observed that coexistence of HDL-C < 15 mg/dL and ΤG > 180 mg/dL had 100% sensitivity and 67.5% specificity for the confirmation of VL. The corresponding positive and negative predictive values were 59.4% and 100%, respectively. Coexistence of high TGs and low HDL-C values may suggest VL infection in a febrile patient.

References

Oct 5, 2001·The Netherlands Journal of Medicine·H J van LeeuwenK P van Kessel
Apr 23, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Evagelos LiberopoulosMoses Elisaf
Dec 25, 2008·Journal of Lipid Research·Robert W MahleyYadong Huang
Apr 21, 2012·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Evangelos LiberopoulosMoses Elisaf
Jan 15, 2013·Journal of Clinical Lipidology·Aris P AgouridisMoses S Elisaf
Jun 13, 2014·European Journal of Clinical Investigation·Evangelos N LiberopoulosMoses Elisaf
May 10, 2017·Infection·Sebastian Filippas-NtekouanMoses Elisaf

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Citations

Jul 6, 2021·Parasitology·Sajad RashidiEugenio Antonio Carrera Silva

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