Diagnostic markers and risk factors of cytomegalovirus infection and disease in renal allograft recipients

Scandinavian Journal of Infectious Diseases
I HökebergL Grillner

Abstract

In a prospective study, the incidences of CMV infection and disease were 56 and 23%, respectively, during the first 6 months following kidney transplantation. Viremia was found in all patients with CMV disease and arthralgia was present in 71% prior to the development of CMV disease. The positive predictive value for CMV disease reached up to 90% for viremia and arthralgia in combination. Viruria was poorly correlated to viremia and hence CMV disease. The majority of patients (93%) who developed CMV disease had a seropositive donor, and viremia was significantly more common in patients who received CMV-seropositive kidneys. CMV disease was more common in CMV-seronegative recipients than in seropositive recipients. The 1-year graft survival rate was 75% in the entire study group. In patients with CMV viremia and disease, the rates were 78 and 73%, respectively. Antiviral treatment was initiated within 3 weeks of viremia detection in the 6 patients with CMV disease who survived. We found that the combination of arthralgia and viremia was a useful predictor of CMV disease and that recipients of CMV-seropositive allografts were at a greater risk of developing CMV disease. To obtain an early diagnosis and commence an early treatment...Continue Reading

References

Oct 1, 1975·The Journal of Infectious Diseases·M FialaL B Guze
Feb 1, 1990·Journal of Virological Methods·B Zweygberg WirgartL Grillner
Sep 1, 1990·Reviews of Infectious Diseases·R H Rubin
Sep 1, 1990·Reviews of Infectious Diseases·H H Balfour
Nov 1, 1981·Reviews of Infectious Diseases·J Glenn
Jan 1, 1994·Scandinavian Journal of Infectious Diseases·A BoehlerG Keusch

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Citations

Jan 5, 2000·Transplantation Proceedings·G MorayM Haberal
Mar 15, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Angelito YangoReginald Gohh
Feb 12, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·V KliemF Rohde
Jun 18, 1998·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H RollagK P Nordal
Jun 26, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M DegréK P Nordal
Jun 22, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S SagedalH Rollag
Dec 10, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·O L CaballeroA J Simpson
Jan 11, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·V H Aquino, L T Figueiredo
Nov 23, 2006·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J CarstensM Madsen

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