PMID: 26817104Jan 29, 2016Paper

DIAGNOSTIC MARKERS FOR CHRONIC PANCREATITIS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH DIFFERENT PHENOTYPE

Ėksperimental'nai︠a︡ i klinicheskai︠a︡ gastroėnterologii︠a︡ = Experimental & clinical gastroenterology
L V Zhuravlyova, Shekhovtsova Y A

Abstract

The purpose--to study the relationships between levels of apelin, elastase-1 and tumor necrosis factor-α (TNF-α) in patients with chronic pancreatitis (CP), type 2 diabetes mellitus (T2DM) and with combined course of its with a different phenotype. The investigation involved of 114 patients with CP, type 2 diabetes mellitus and with combined course of its with a different phenotype. The control group consisted of 20 healthy individuals. It was found that patients with combined course of CP and type 2 diabetes with overweight had significantly higher hyperapelinemia and hyper-TNF-α-emia (p < 0.05). Patients of all study groups revealed a close correlation between apelin and TNF-α (p < 0.05), a significant correlation between apelin and elastase-1 (p < 0.05). As a result of analysis of variance identified significant contribution of study diseases and different phenotypes in levels of apelin, TNF-α and elastase-1. The results of the study suggest that the levels of apelin, TNF-α and elastase-1 are important diagnostic markers of CP in patients with type 2 diabetes mellitus.

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