Diagnostic morphometry of isolated lymph node cells from patients with mycosis fungoides and Sézary's syndrome

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
E M van der LooC J Meijer

Abstract

Mycosis fungoides (MF) and Sézary's syndrome are cutaneous T cell lymphomas, characterized by the presence of lymphoid cells with deeply indented nuclei (CMC) in the infiltrate. In order to find objective criteria for the diagnosis of early MF involvement of lymph nodes from patients with MF, we performed morphometric analysis of lymphoid cells in lymph node cell suspensions measuring the degree of nuclear indentation as expressed by the nuclear contour index (NCI). Statistical discriminant analysis was used to analyze the differences in the NCI histograms between lymph nodes without and with MF involvement and to select the most discriminating parameters for diagnostic classification. Using a training set of 6 lymph nodes from patients with unrelated diseases and 8 lymph nodes from patients involved by cutaneous T cell lymphomas, the mean and standard deviation of the NCI histograms were selected as the most discriminating parameters. All lymph nodes from the training set were assigned to the correct diagnostic classification group with a probability over 90%. The predictive value of the morphometric classification was tested on a set of 12 enlarged lymph nodes from patients with MF. The histological diagnosis was used as a re...Continue Reading

References

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Citations

Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·H Schultz, J Ersbøll
Jan 1, 1991·Electron Microscopy Reviews·R J SokolN T James
Mar 1, 1983·Journal of Clinical Pathology·P van der ValkC J Meijer
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May 1, 1985·Histopathology·E C OomsR W Veldhuizen
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Apr 20, 2010·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Andrea V BurriTimothy D Spector
Jan 1, 1990·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·R J SokolJ Wales

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