Diagnostic performance and factors influencing the accuracy of EUS-FNA of pancreatic neuroendocrine neoplasms

Journal of Gastroenterology
Susumu HijiokaKenji Yamao

Abstract

Multiple studies have investigated sampling adequacy of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for pancreatic neuroendocrine neoplasms (pNENs). However, none have described the diagnostic performance of EUS-FNA for pNENs, or the influencing factors. The aim of this study was to evaluate the diagnostic accuracy of EUS-FNA, with post-operative pathological diagnosis as the gold standard, and factors predictive of inadequate EUS sampling. From 1998 to 2014, a total of 698 patients underwent pancreatic resection and 1455 patients underwent EUS-FNA sampling for pancreatic lesions. A total of 410 cases underwent both surgical resection and preceding EUS-FNA. Of these, 60 cases (49 true pNEN, nine non-diagnostic, two misdiagnoses) were included. We studied diagnostic performance of EUS-FNA and factors that were associated with failed diagnosis. Of the 60 cases, EUS-FNA yield was 49 true-positive cases, two misdiagnoses, and nine non-diagnostic cases (including six suggestive cases). Sensitivity, specificity, and accuracy were 84.5, 99.4, and 97.3 %, respectively; including the six suggestive cases, diagnostic values were 94.8 % sensitivity (55/58), 99.4 % specificity (350/352), and 98.7 % accuracy (405/410). In ...Continue Reading

References

Jun 1, 2005·Journal of the American College of Surgeons·Theodossios Papavramidis, Spiros Papavramidis
Jul 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Megan Dann FesinmeyerDeborah J Bowen
Sep 13, 2006·Virchows Archiv : an International Journal of Pathology·G RindiUNKNOWN European Neuroendocrine Tumor Society (ENETS)
Nov 23, 2006·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Rodney H Reznek
Mar 23, 2010·Gastrointestinal Endoscopy·Shireen A PaisJohn M DeWitt
May 8, 2010·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Kensuke KubotaAtsushi Nakajima
Nov 13, 2010·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Rachel B LewisEdina Paal
Mar 26, 2011·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·J GornalsJ Fabregat
Oct 4, 2011·Digestive Diseases and Sciences·Muslim AtiqJeffrey H Lee
Aug 17, 2012·The American Journal of Surgical Pathology·Satu Maria RemesJohanna Arola
Dec 15, 2012·Chinese Journal of Cancer·Cynthia RoRun Yu
Jun 5, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Fabia AttiliAlberto Larghi
Jun 27, 2013·World Journal of Gastroenterology : WJG·Srinivas R PuliDavid Forcione
Dec 4, 2013·Scandinavian Journal of Gastroenterology·Jun UnnoTooru Shimosegawa
Jan 17, 2014·Digestive Diseases and Sciences·Yousuke NakaiKazuhiko Koike
Feb 14, 2014·Endoscopy·Takeshi OguraKazuhide Higuchi
Feb 3, 2015·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Masayuki KitanoMasatoshi Kudo

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Citations

Aug 20, 2016·Journal of Gastroenterology·Tetsuhide ItoMasayuki Imamura
Oct 18, 2016·Journal of Gastroenterology·Neel Sharma
Dec 22, 2017·Cancer Cytopathology·Lisa LaskiewiczXiaofei Wang
Oct 14, 2017·United European Gastroenterology Journal·Antonio FacciorussoNicola Muscatiello
Jul 6, 2018·Expert Review of Anticancer Therapy·Lingaku LeeRobert T Jensen
Nov 6, 2018·Scandinavian Journal of Gastroenterology·B BunganičM Zavoral
Mar 13, 2020·Minerva gastroenterologica e dietologica·Antonio Facciorusso
Aug 7, 2019·Journal of Medical Ultrasonics·Yasunobu Yamashita, Masayuki Kitano
Nov 7, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wenjie LiangTianye Niu
Aug 28, 2021·Journal of Clinical Medicine·Kosuke TakahashiKazuhiko Nakao

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Methods Mentioned

BETA
surgical resection
urine collection

Software Mentioned

SPSS

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