Abstract
Multiple studies have investigated sampling adequacy of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for pancreatic neuroendocrine neoplasms (pNENs). However, none have described the diagnostic performance of EUS-FNA for pNENs, or the influencing factors. The aim of this study was to evaluate the diagnostic accuracy of EUS-FNA, with post-operative pathological diagnosis as the gold standard, and factors predictive of inadequate EUS sampling. From 1998 to 2014, a total of 698 patients underwent pancreatic resection and 1455 patients underwent EUS-FNA sampling for pancreatic lesions. A total of 410 cases underwent both surgical resection and preceding EUS-FNA. Of these, 60 cases (49 true pNEN, nine non-diagnostic, two misdiagnoses) were included. We studied diagnostic performance of EUS-FNA and factors that were associated with failed diagnosis. Of the 60 cases, EUS-FNA yield was 49 true-positive cases, two misdiagnoses, and nine non-diagnostic cases (including six suggestive cases). Sensitivity, specificity, and accuracy were 84.5, 99.4, and 97.3 %, respectively; including the six suggestive cases, diagnostic values were 94.8 % sensitivity (55/58), 99.4 % specificity (350/352), and 98.7 % accuracy (405/410). In ...Continue Reading
References
Feb 15, 2000·Radiology·R F ThoeniP B Shyn
Apr 24, 2001·Journal of Human Hypertension·J P BaguetJ M Mallion
Jun 1, 2005·Journal of the American College of Surgeons·Theodossios Papavramidis, Spiros Papavramidis
Jul 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Megan Dann FesinmeyerDeborah J Bowen
Sep 13, 2006·Virchows Archiv : an International Journal of Pathology·G RindiUNKNOWN European Neuroendocrine Tumor Society (ENETS)
Nov 23, 2006·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Rodney H Reznek
Nov 27, 2008·Journal of Gastroenterology and Hepatology·Hiroki SakamotoMasatoshi Kudo
Jan 2, 2009·Scandinavian Journal of Gastroenterology·Rajesh PuriFlorin Gorunescu
Nov 21, 2009·American Journal of Clinical Pathology·Holly BurfordNirag Jhala
Mar 23, 2010·Gastrointestinal Endoscopy·Shireen A PaisJohn M DeWitt
May 8, 2010·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Kensuke KubotaAtsushi Nakajima
Aug 18, 2010·Radiology·Chanjuan ShiRalph H Hruban
Nov 13, 2010·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Rachel B LewisEdina Paal
Mar 26, 2011·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·J GornalsJ Fabregat
Oct 4, 2011·Digestive Diseases and Sciences·Muslim AtiqJeffrey H Lee
Jan 10, 2012·Human Pathology·Chad M McCallRalph H Hruban
Aug 17, 2012·The American Journal of Surgical Pathology·Satu Maria RemesJohanna Arola
Aug 18, 2012·Gastrointestinal Endoscopy·Alberto LarghiGuido Rindi
Oct 24, 2012·Journal of Gastroenterology·Shin HabaNaoya Sakamoto
Dec 15, 2012·Chinese Journal of Cancer·Cynthia RoRun Yu
Jun 5, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Fabia AttiliAlberto Larghi
Jun 27, 2013·World Journal of Gastroenterology : WJG·Srinivas R PuliDavid Forcione
Jul 11, 2013·Cancer Cytopathology·Kari HooperIsam A Eltoum
Dec 4, 2013·Scandinavian Journal of Gastroenterology·Jun UnnoTooru Shimosegawa
Jan 17, 2014·Digestive Diseases and Sciences·Yousuke NakaiKazuhiko Koike
Feb 14, 2014·Endoscopy·Takeshi OguraKazuhide Higuchi
May 9, 2014·Virchows Archiv : an International Journal of Pathology·Gabriele CarlinfanteLorenzo Camellini
Jun 4, 2014·Gastrointestinal Endoscopy·Taiki KudoUNKNOWN Japan EUS-FNA Negative Pressure Suction Study Group
Jul 1, 2012·Endoscopic Ultrasound·Ricardo L GancRodrigo Altenfelder
Jul 22, 2014·Cancer Cytopathology·Jessica M FarrellZ Laura Tabatabai
Feb 3, 2015·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Masayuki KitanoMasatoshi Kudo
Oct 16, 2015·Digestive Diseases and Sciences·Hiroshi KawakamiNaoya Sakamoto
Citations
Aug 20, 2016·Journal of Gastroenterology·Tetsuhide ItoMasayuki Imamura
Oct 18, 2016·Journal of Gastroenterology·Neel Sharma
Dec 25, 2016·Journal of Gastroenterology·Susumu HijiokaVikram Bhatia
Mar 3, 2017·Internal Medicine·Mari IwasakiHideyuki Hiraishi
Dec 22, 2017·Cancer Cytopathology·Lisa LaskiewiczXiaofei Wang
May 23, 2018·Endoscopic Ultrasound·Shuntaro MukaiYuichi Nagakawa
Oct 14, 2017·United European Gastroenterology Journal·Antonio FacciorussoNicola Muscatiello
Jul 6, 2018·Expert Review of Anticancer Therapy·Lingaku LeeRobert T Jensen
Jul 29, 2018·Annals of Surgical Oncology·Yoshihide NannoTakumi Fukumoto
Nov 6, 2018·Scandinavian Journal of Gastroenterology·B BunganičM Zavoral
Sep 17, 2019·World Journal of Gastrointestinal Endoscopy·Clara Benedetta ContiRoberto Grassia
Dec 21, 2019·Journal of Gastroenterology·Yusuke KuritaYasuhiro Shimizu
Mar 13, 2020·Minerva gastroenterologica e dietologica·Antonio Facciorusso
Nov 8, 2016·World Journal of Gastroenterology : WJG·Jia-Ying ChenTian-Ming Cheng
Aug 7, 2019·Journal of Medical Ultrasonics·Yasunobu Yamashita, Masayuki Kitano
Jun 5, 2020·Endoscopy·Salvatore PaiellaRoberto Salvia
Nov 7, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wenjie LiangTianye Niu
Mar 7, 2021·Diagnostics·Tatsuya IshiiKuniyuki Takahashi
May 12, 2021·Diagnostic Cytopathology·Wisam Sbeit, Tawfik Khoury
Aug 28, 2021·Journal of Clinical Medicine·Kosuke TakahashiKazuhiko Nakao