Diagnostic Performance of 18F-Fluciclovine in Detection of Prostate Cancer Bone Metastases

Clinical Nuclear Medicine
Albert ChauHossein Jadvar

Abstract

F-fluciclovine is a synthetic amino acid radiotracer that has recently been approved in Europe and the United States for PET imaging in men with biochemical recurrence (BCR) of prostate cancer after prior definitive treatment. Accurate identification of the sites of disease in patients presenting with BCR of prostate cancer is important in determining the appropriate treatment. Bone is the most frequent site of metastatic disease in patients with prostate cancer. We conducted a comprehensive review of the available preclinical and clinical data on the diagnostic performance of F-fluciclovine PET/CT in an attempt to draw practical and general conclusions on the utility and limitations of F-fluciclovine PET/CT in localization of osseous metastatic disease in prostate cancer. The cumulative preclinical data and results of some retrospective and 2 prospective clinical studies suggest that F-fluciclovine can detect early bone marrow involvement in patients with BCR of prostate cancer and negative prior bone-specific imaging findings. F-fluciclovine PET/CT seems to offer useful information for early detection of bone metastases in men with BCR of prostate cancer. Additional investigations will be needed to compare the diagnostic perf...Continue Reading

References

Apr 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew R SmithCelestia S Higano
Mar 7, 2006·Cancer·Kenneth R HessJames L Abbruzzese
Jun 19, 2010·Annals of Nuclear Medicine·Ukihide TateishiE Edmund Kim
Jan 25, 2011·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Blanca PañoCarlos Nicolau
Oct 8, 2014·Clinical Nuclear Medicine·Chen-Tian ShenQuan-Yong Luo
Dec 6, 2014·Seminars in Nuclear Medicine·Hossein JadvarPeter S Conti
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Sep 5, 2015·World Journal of Radiology·Gerard J O'SullivanCarmel G Cronin
Oct 4, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Andrei H IagaruHossein Jadvar

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Citations

Jan 29, 2019·Clinical Nuclear Medicine·Bo ChenYang Lu
May 31, 2019·Nuclear Medicine Communications·Asim AfaqJamshed Bomanji
Jul 10, 2019·Clinical Nuclear Medicine·Chelsea R SchmittKevin J Sawyer
Dec 12, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Cristina NanniDavid M Schuster
Feb 24, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Jad S HusseiniOnofrio A Catalano
Mar 21, 2021·Nuclear Medicine Communications·Daniel GarzaRathan M Subramaniam
Aug 15, 2021·European Journal of Radiology·Farshad MoradiAndrei Iagaru

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