Diagnostic performance of CA 125, HE4, and risk of Ovarian Malignancy Algorithm for ovarian cancer

Journal of Clinical Laboratory Analysis
Boyeon KimSang Won Han

Abstract

We evaluated the diagnostic performance of CA 125, HE4, and ROMA for ovarian cancer in Koreans and set optimal cutoffs. Serum levels of HE4 and CA 125 and the ROMA score were determined in 762 patients with benign gynecological disease and 70 with ovarian cancer. Receiver operating characteristic curves were constructed to calculate the areas under the curve (AUC). CA 125, HE4, and ROMA exhibiting maximum Youden index were determined, respectively, as the optimal cutoffs, and sensitivity and specificity were evaluated by applying those cutoffs. In benign diseases, CA 125 significantly increased in patients with uterine myoma, adenomyosis, endometrial pathology, or endometriosis, but HE4 only increased in patients with adenomyosis. For the diagnosis of ovarian cancer, the combination of CA 125, HE4, and age showed the highest AUC value of 0.892 in the premenopausal group, and ROMA demonstrated the best diagnostic performance, with an AUC of 0.935 in postmenopausal patients. When the optimal cutoff values for CA 125 and HE4 were applied, the sensitivities of CA 125, HE4, and ROMA in premenopausal women were all the same at 0.714, while the specificities were 0.841, 0.974, and 0.972, respectively. In the postmenopausal group, the ...Continue Reading

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Citations

Nov 14, 2019·Diagnostics·Mallika AsarMette Soendergaard
Mar 7, 2021·International Journal of Molecular Sciences·Izabela KokotEwa Maria Kratz
Mar 23, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·F GkrozouM Paschopoulos
Apr 4, 2021·International Journal of Environmental Research and Public Health·Mateusz KozłowskiAneta Cymbaluk-Płoska
Apr 2, 2021·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D TimmermanC Fotopoulou
Jun 12, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Dirk TimmermanChristina Fotopoulou
Jun 11, 2021·Facts, Views & Vision in ObGyn·D TimmermanC Fotopoulou
Oct 1, 2021·The Journal of International Medical Research·Mariona RiusFrancisco Carmona

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