Diagnostic performance of CT versus MR in detecting aldosterone-producing adenoma in primary hyperaldosteronism (Conn's syndrome)

European Radiology
R K LingamRodney Reznek

Abstract

The aim of the present study is to compare the diagnostic performance of CT and MR imaging in detecting aldosterone-producing adenoma and to compare the interobserver variability in the detection of an aldosterone-producing adenoma on CT and MR. A retrospective study of 34 patients with primary hyperaldosteronism was performed. A total of 17 cases of aldosterone-producing adenoma and 17 cases of bilateral adrenal hyperplasia were included. The final diagnosis of an adenoma was made by surgery with histological confirmation, whereas that of bilateral adrenal hyperplasia was made on adrenal venous sampling or a good biochemical and clinical response following medical treatment alone and in the absence of a unilateral radiological abnormality. The CT (n=30) and MR (n=24) scans were reviewed independently by two radiologists experienced in adrenal imaging, who were unaware of the cause of the primary hyperaldosteronism. The diagnostic performances of both observers in detecting an aldosterone-producing adenoma on CT and MR imaging were compared. The 16 adenomatous nodules that were detected on imaging ranged from 1 to 4.75 cm in diameter. The calculated sensitivity and specificity for detecting aldosterone-producing adenoma were 87...Continue Reading

Citations

Mar 28, 2008·Current Urology Reports·Daniel R Simon, Michael A Palese
Mar 15, 2005·Best Practice & Research. Clinical Endocrinology & Metabolism·S A SohaibR H Reznek
Jul 1, 2005·Seminars in Ultrasound, CT, and MR·Nomdo S Renken, Gabriel P Krestin
Jul 11, 2007·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Shilpan M PatelBeata Brown
Sep 19, 2006·Best Practice & Research. Clinical Endocrinology & Metabolism·Caroline Schirpenbach, Martin Reincke
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Dec 28, 2018·The Journal of Clinical Endocrinology and Metabolism·Davis SamAlexander A Leung
Feb 23, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Caroline Schirpenbach, Martin Reincke
Jul 14, 2009·Nuclear Medicine Communications·Alberto MazzaEdoardo Casiglia
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