Diagnostic performance of gadoxetic acid (Primovist)-enhanced MR imaging versus CT during hepatic arteriography and portography for small hypervascular hepatocellular carcinoma

Medicine
Sun Young YimYun Hwan Kim

Abstract

To compare the diagnostic performance of gadoxetic acid-enhanced magnetic resonance imaging (MRI) with that of computed tomography (CT) during hepatic arteriography and arterial portography (CT HA/AP) for detecting hepatocellular carcinoma (HCC) from small hypervascular nodules.This retrospective study included 38 patients with 131 hypervascular nodules (≤2 cm) who had underwent MRI and CT HA/AP within a 2-week interval. Two observers analyzed MRI while other 2 observers analyzed CT HA/AP. Thereafter, MRI observers reviewed the CT HA/AP and magnetic resonance (MR) images again using both modalities. HCC was diagnosed by pathologic or imaging studies according to American Association for the Study of Liver Diseases (AASLD) criteria. Alternative free-response receiver operating characteristic (ROC) analysis was performed on a lesion-by-lesion basis. Diagnostic accuracy (area under the ROC curve [Az]), sensitivity, specificity, and positive and negative predictive values were calculated.The pooled Az was significantly higher for the combined modalities (0.946) than for MRI alone (0.9, P = 0.004), and for MRI than for CT HA/AP alone (0.827, P = 0.0154). Subgroup analysis for HCC ≤1 cm showed the sensitivity of the combined modaliti...Continue Reading

References

Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixAmerican Association for the Study of Liver Diseases
Oct 14, 2011·The New England Journal of Medicine·Hashem B El-Serag
Mar 20, 2012·Journal of Hepatology·European Association For The Study Of The Liver, European Organisation For Research And Treatment Of Cancer

Citations

Sep 9, 2017·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Xijiao LiuBin Song
Jul 24, 2020·Journal of Magnetic Resonance Imaging : JMRI·Jae Hyun KimJeong Min Lee
Jun 30, 2017·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Mustafa KurucayWolfgang M Thaiss

Related Concepts

Gadoxetic acid
Arteriography
Radiographic contrast media
Structure of Hepatic Vein
Liver Carcinoma
Liver Circulation
Malignant Neoplasm of Liver
Magnetization Transfer Contrast Imaging
Splenoportography
Retrospective Studies

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