Diagnostic Performance of In-Phase and Opposed-Phase Chemical-Shift Imaging for Differentiating Benign and Malignant Vertebral Marrow Lesions: A Meta-Analysis

AJR. American Journal of Roentgenology
Chong Hyun SuhSun Hwa Lee

Abstract

The purpose of this study was to assess the diagnostic performance of in-phase and opposed-phase chemical-shift imaging (CSI) for differentiating benign and malignant vertebral bone marrow lesions (BMLs). The PubMed and EMBASE databases were searched for diagnostic accuracy studies comparing conventional gradient-echo CSI or the Dixon method for differentiating benign and malignant vertebral BMLs with histopathologic or best-value comparator results. Methodologic quality was assessed with the Quality Assessment of Diagnostic Accuracy Studies 2 tool. Bivariate modeling and hierarchical summary ROC (HSROC) modeling were performed to evaluate the diagnostic performance of CSI. For heterogeneity exploration, we performed meta-regression analyses. Twelve studies including 663 lesions of 591 patients were included. CSI showed a pooled sensitivity of 0.92 (95% CI, 0.84-0.96), pooled specificity of 0.89 (95% CI, 0.81-0.93), and HSROC AUC of 0.95 (95% CI, 0.93-0.97) for differentiating benign from malignant vertebral BMLs. The corresponding values for differentiating benign from malignant compression fractures were 0.96 (95% CI, 0.81-0.99), 0.89 (95% CI, 0.83-0.93), and 0.93 (95% CI, 0.91-0.95). In meta-regression analysis, minimum TR (...Continue Reading

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Citations

Jul 17, 2019·Skeletal Radiology·Niels van VuchtAsif Saifuddin
Sep 30, 2020·Seminars in Musculoskeletal Radiology·James F Griffith
Aug 21, 2020·Skeletal Radiology·Asif SaifuddinSyed Ehtasham Junaid
Sep 27, 2020·Skeletal Radiology·Nehal SinglaAsif Saifuddin
Feb 23, 2021·Diagnostic and Interventional Imaging·Ricardo DonnersDorothee Harder
May 29, 2021·Journal of Clinical Orthopaedics and Trauma·G HegdeR Botchu

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