Diagnostic performance of isolated-check visual evoked potential versus retinal ganglion cell-inner plexiform layer analysis in early primary open-angle glaucoma

BMC Ophthalmology
XiangWu Chen, YingXi Zhao

Abstract

The purpose of this study was to compare the diagnostic performance of isolated-check visual evoked potential (icVEP) with that of retinal ganglion cell-inner plexiform layer (GCILP) analysis using optical coherence tomography (OCT). A total of 45 patients were enrolled: 25 patients with open-angle glaucoma and 20 healthy patients. All patients underwent a complete ophthalmological examination. Moreover, the OCT examination was used to analyze the structures of the GCIPL. The icVEP technique was used to detect the transmission function of the magnocellular pathway, which is mainly managed by the retinal ganglion cells. The quantitative and qualitative comparisons between the diagnostic power of GCIPL analysis and that of icVEP were performed. The areas under the receiver operating characteristic curves (AUC) of GCIPL analysis and icVEP were compared using the Clarke-Pearson method. The sensitivity and specificity of the two techniques were analyzed and compared using the McNemar test. With the quantitative comparison, the AUC of icVEP (AUC = 0.892) was higher than that of GCIPL analysis (AUC = 0.814). However, there was no statistical significance between the AUCs of icVEP and GCIPL (P > 0.05). With the qualitative comparison, ...Continue Reading

References

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Citations

Jan 10, 2020·Journal of Glaucoma·Natasha N KolomeyerJoseph F Panarelli
Sep 10, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yanjie TianXuemin Li
Jul 11, 2019·Neural Regeneration Research·Hui-Jun ZhangKwok-Fai So
Jan 31, 2020·Neural Regeneration Research·Lian LiuJing-Xiang Zhong
Jul 14, 2020·Progress in Retinal and Eye Research·Gala BeykinJeffrey L Goldberg
Dec 7, 2019·Journal of Glaucoma·Cassia SengerJayter S Paula

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Software Mentioned

Neucodia
Cirrus
icVEP

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