Diagnostic performance of magnetic resonance imaging in the detection of appendicitis in adults: a meta-analysis

Academic Radiology
Richard L Barger, Kiran R Nandalur

Abstract

Perform a meta-analysis evaluating the diagnostic performance of magnetic resonance imaging (MRI) for the diagnosis of acute appendicitis. MEDLINE and EMBASE were queried between January 1995 and December 2009. Prospective and retrospective studies were included if they: used MRI as a diagnostic test for appendicitis, used pathology or clinical follow-up as the reference standard, and reported absolute number of true-positive, true-negative, false-positive, and false-negative results, or stated sufficient data to derive these values. Summary sensitivity, summary specificity, positive and negative likelihood ratios (LR+) and (LR-), and diagnostic odds ratio were calculated. Heterogeneity of the results was assessed using Forest plots and the value of inconsistency index (I(2)). The inclusion criteria were fulfilled by eight articles with a total of 363 patients (mean age 26.9 ± 7.2 years; 86.2 % female). The appendix was not found in eight patients, with one article not reporting such data. The summary sensitivity was 97% (92%-99% at 95% confidence interval [CI]) and summary specificity was 95% (CI: 94%-99%), with a LR+ of 16.3 (CI: 9.1-29.1) and a LR- of 0.09 (CI: 0.04-0.197). Diagnostic odds ratio was 299.85 (CI: 97.5-921.61)....Continue Reading

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Jun 9, 2012·Pediatric Radiology·Michael M MooreDanielle K B Boal
Jun 16, 2012·Radiology·Marjolein M N LeeuwenburghJaap Stoker
Jan 21, 2014·Pediatric Radiology·Michael M MooreDanielle K B Boal
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