Diagnostic performance of MRI for assessment of response to neoadjuvant chemoradiotherapy in oesophageal cancer

The British Journal of Surgery
S E VollenbrockA Bartels-Rutten

Abstract

Patients with a pathological complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT) for oesophageal cancer may benefit from non-surgical management. The aim of this study was to determine the diagnostic performance of visual response assessment of the primary tumour after nCRT on T2-weighted (T2W) and diffusion-weighted (DW) MRI. Patients with locally advanced oesophageal cancer who underwent T2W- and DW-MRI (1·5 T) before and after nCRT in two hospitals, between July 2013 and September 2017, were included in this prospective study. Three radiologists evaluated T2W images retrospectively using a five-point score for the assessment of residual tumour in a blinded manner and immediately rescored after adding DW-MRI. Histopathology of the resection specimen was used as the reference standard; ypT0 represented a pCR. Sensitivity, specificity, area under the receiver operating characteristic (ROC) curve (AUC) and interobserver agreement were calculated. Twelve of 51 patients (24 per cent) had a pCR. The sensitivity and specificity of T2W-MRI for detection of residual tumour ranged from 90 to 100 and 8 to 25 per cent respectively. Respective values for T2W + DW-MRI were 90-97 and 42-50 per cent. AUCs for the three readers...Continue Reading

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Citations

Jun 5, 2019·The British Journal of Surgery·R C Grossman
Jul 30, 2020·Annals of Gastroenterological Surgery·Tania Triantafyllou, Bas Wijnhoven
Jun 24, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Sophie E VollenbrockAnnemarieke Bartels-Rutten
Apr 1, 2021·Radiology·Sangjune Laurence LeeMichael F Bassetti
May 29, 2021·The Surgical Clinics of North America·Charles T BakhosAbbas E Abbas

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Methods Mentioned

BETA
biopsies
imaging techniques

Clinical Trials Mentioned

NCT02139488
NCT02125448

Software Mentioned

SPSS®
Stata®

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