Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in coronary artery disease: A systematic review and meta-analysis

International Journal of Cardiology
Song-Bai DengQiang She

Abstract

The study performed a meta-analysis of the diagnostic performance of fractional flow reserve (FFR) derived from coronary computed tomography angiography (FFRCT) to assess the functional significance of coronary stenosis using FFR as the reference standard. We searched the electronic databases of PubMed, EMBASE, The Chorance Library, Medion and Web of Science for relevant articles published until August 2014. Pooled estimates of sensitivity, specificity, positive (LR+) and negative likelihood ratios (LR-) with the corresponding 95% confidence intervals (CIs) and the summary receiver operating characteristic curve (SROC) were determined. Five studies, 706 patients and 1165 vessels or lesions were included in the meta-analysis. The pooled sensitivity and specificity for FFRCT at the per-patient level were 90% (95% CI, 85%-93%) and 72% (95% CI, 67%-76%), respectively. The corresponding pooled LR+ and LR- were 3.70 (95% CI, 2.11-6.49) and 0.15 (95% CI, 0.11-0.22), respectively. The pooled sensitivity and specificity for FFRCT on the per-vessel or per-lesion basis were 83% (95% CI, 79%-87%) and 78% (95% CI, 75%-81%), respectively. Corresponding pooled LR+ and LR- were 3.75 (95% CI, 2.09-6.74) and 0.22 (95% CI, 0.18-0.29), respectivel...Continue Reading

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Citations

May 16, 2015·International Journal of Cardiology·Uğur Aksu, Selim Topcu
Mar 30, 2017·Pflügers Archiv : European journal of physiology·Kyung Eun LeeEun Bo Shim
Nov 11, 2017·Biomedical Engineering Online·Xin LiuHeye Zhang
May 24, 2017·European Heart Journal Supplements : Journal of the European Society of Cardiology·Francesco SecchiFrancesco Sardanelli
May 16, 2019·Angiology·Thomas F WhayneAhmed Abdel-Latif

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