Diagnostic Performance of Shear Wave Elastography in Patients With Autoimmune Liver Disease

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
Changtian LiAnthony E Samir

Abstract

To assess performance of shear wave elastography for evaluation of fibrosis and the histologic stage in patients with autoimmune liver disease (ALD) and to validate previously established advanced fibrosis cutoff values in this cohort. Shear wave elastography was performed on patients with ALD with an Aixplorer ultrasound system (SuperSonic Imagine, Aix-en-Provence, France) using an SC6-1 transducer. The median estimated tissue Young modulus was calculated from sets of 8 to 10 elastograms. A blinded, subspecialty-trained pathologist reviewed biopsy specimens. The METAVIR classification was used to stage liver fibrosis and necroinflammation. Steatosis was graded from 0 to 4+. The Kendall τ-b correlation test was performed to identify the correlation between the estimated tissue Young modulus and fibrosis, steatosis, and the necroinflammatory score. The Spearman correlation test was performed to identify the correlation between the estimated tissue Young modulus and clinical data. The diagnostic performance of shear wave elastography for differentiating METAVIR stage F2 or higher from F0 and F1 fibrosis was evaluated by a receiver operating characteristic (ROC) curve analysis. Fifty-one patients with ALD were analyzed. The estima...Continue Reading

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Citations

Jun 9, 2020·Expert Review of Gastroenterology & Hepatology·Xian XingLi Yang
Sep 20, 2018·World Journal of Gastroenterology : WJG·Jae Yoon JeongJoo Hyun Sohn

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