Diagnostic performance of the "MESACUP anti-Skin profile TEST"

European Journal of Dermatology : EJD
Orsolya N HorváthMiklós Sárdy

Abstract

The "MESACUP anti-Skin profile TEST" is a new, commercially available ELISA kit to detect circulating IgG autoantibodies against desmoglein 1, desmoglein 3, BP180, BP230, and type VII collagen, both simultaneously and more rapidly than previous assays. The aim of this study was to evaluate the diagnostic accuracy of this kit for the diagnosis of pemphigus foliaceus, pemphigus vulgaris, bullous pemphigoid and epidermolysis bullosa acquisita. Dual-centre retrospective study in which 138 patients with autoimmune blistering diseases were compared to 40 controls Using the MESACUP anti-Skin profile TEST, both sensitivities and specificities for desmoglein 1, desmoglein 3, BP180, BP230, and type VII collagen autoantibodies were similar to those obtained using previous, specific ELISA systems and 88% of the results were concordant without any significant difference. The MESACUP anti-Skin profile TEST had a similar performance to previously produced ELISA systems. The novel kit can be used for rapid diagnosis of most common autoimmune blistering diseases and is especially suitable for identifying overlapping disorders.

Citations

Dec 27, 2018·The British Journal of Dermatology·S SunX Zeng
Sep 1, 2016·Expert Review of Clinical Immunology·Artem VorobyevEnno Schmidt
Dec 16, 2017·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M M HoltscheE Schmidt
Feb 12, 2019·Frontiers in Immunology·Mayumi Kamaguchi, Hiroaki Iwata
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Sep 26, 2019·Frontiers in Immunology·Sandra SaschenbreckerWolfgang Schlumberger
Sep 5, 2018·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Nina van BeekEnno Schmidt
Sep 5, 2018·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Nina van BeekEnno Schmidt
Feb 1, 2020·Journal of the American Academy of Dermatology·Nina van BeekKristin Rentzsch
Apr 8, 2021·Deutsches Ärzteblatt International·Nina van BeekEnno Schmidt
Aug 10, 2021·Deutsches Ärzteblatt International·Nina van BeekEnno Schmidt

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