Diagnostic Performance of Ultrasound-Guided Fine-Needle Aspiration of Nonpalpable Breast Lesions in a Multidisciplinary Setting: The Institut Curie's Experience

American Journal of Clinical Pathology
Josep A Farras RocaJ Klijanienko

Abstract

To assess the diagnostic performance of ultrasound-guided fine-needle aspiration (USFNA) in nonpalpable breast lesions (NPBLs) in a multidisciplinary setting. In total, 2,601 NPBLs underwent USFNA by a radiologist-pathologist team. Gold-standard diagnosis was based on surgery, core-needle biopsy, or 1-year imaging follow-up. USFNA's diagnostic performance was analyzed in different clinical and imaging subgroups. USFNA's sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were, respectively, 92.6% (95% confidence interval [CI], 90.8%-94.2%), 96.8% (95% CI, 95.8%-97.6%), 94.8% (95% CI, 93.2%-96.1%), and 95.4% (95% CI, 94.3%-96.4%). The best PPV was achieved in Breast-Imaging Reporting and Data System (BI-RADS) categories 4C and 5 and the best NPV in BI-RADS categories 2, 3, and 4A and in patients younger than 50 years. The mitotic count, BI-RADS categories, associated palpable cancer, and age (<50 or ≥50 years) were statistically independent factors ( P  < .05) between USFNA's false-negative and true-positive results. USFNA is a robust diagnostic procedure in NPBLs. Age and the BI-RADS category of the lesion are important factors determining its performance.

References

Feb 1, 1987·Radiology·B D FornageA Simatos
May 1, 1993·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D RottenM Sandres
Apr 17, 1998·The New England Journal of Medicine·J G ElmoreS W Fletcher
Nov 25, 2003·Cytopathology : Official Journal of the British Society for Clinical Cytology·N SinghC A Wells
Oct 3, 2006·European Radiology·Matthew WallisUNKNOWN European Society of Breast Imaging
Oct 20, 2007·Cytopathology : Official Journal of the British Society for Clinical Cytology·A PogacnikM Rener
Dec 8, 2007·Diagnostic Cytopathology·Alexandre de Almeida BarraSoraya Zhouri Costa e Silva
Sep 30, 2008·Cytopathology : Official Journal of the British Society for Clinical Cytology·G KocjanF Schmitt
Mar 27, 2010·Clinical Radiology·E A M O'FlynnM J Michell
Jun 11, 2011·Ultrastructural Pathology·Aasmund Berner, Torill Sauer
Nov 1, 2011·Journal of Clinical Pathology·S M WillemsP J van Diest
Nov 18, 2011·The Breast : Official Journal of the European Society of Mastology·Beniamino BrancatoNehmat Houssami

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Citations

May 18, 2019·Archives of Pathology & Laboratory Medicine·Kenneth P H Pritzker, Heikki J Nieminen
Aug 25, 2017·Cancer Cytopathology·Miguel A SanchezBritt Marie Ljung
Feb 7, 2020·Insights Into Imaging·Ulrich BickUNKNOWN European Society of Breast Imaging (EUSOBI), with language review by Europa Donna–The European Breast Cancer Coalition

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