Diagnostic performance of whole body dual modality 18F-FDG PET/CT imaging for N- and M-staging of malignant melanoma: experience with 250 consecutive patients

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Michael ReinhardtThomas Tüting

Abstract

To assess the diagnostic performance of positron emission tomography/computed tomography (PET/CT) using (18)F-fluorodeoxyglucose (FDG) for N- and M-staging of cutaneous melanoma. This is a retrospective and blinded study of 250 consecutive patients (105 women, 145 men; age 58 +/- 16 years) who underwent FDG-PET/CT for staging of cutaneous melanoma at different time points in the course of disease. Whole-body FDG-PET/CT was performed 101 +/- 21 minutes postinjection of 371 +/- 41 MBq FDG. Diagnostic accuracy for N- and M-staging was determined for CT alone, PET alone, and PET/CT. PET/CT detected significantly more visceral and nonvisceral metastases than PET alone and CT alone (98.7%, 88.8%, and 69.7%, respectively). PET/CT imaging thus provided significantly more accurate interpretations regarding overall N- and M-staging than PET alone and CT alone. Overall N- and M-stage was correctly determined by PET/CT in 243 of 250 patients (97.2%; 95% CI, 95.2% to 99.4%) compared with 232 patients (92.8%; 95% CI, 89.6% to 96.0%) by PET, and 197 patients (78.8%; 95% CI, 73.7% to 83.9%) by CT. All differences were significant. Accuracy of PET/CT was significantly higher than that of PET and CT for M-staging (0.98 v 0.93 and 0.84) and signi...Continue Reading

References

Jun 1, 1991·The Journal of Surgical Research·K A Kern
May 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D J MacfarlaneR L Wahl
May 20, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J D WagnerJ T Hayes
Jul 27, 2001·Journal of Surgical Oncology·J D WagnerG Hutchins
Aug 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M BalchA Morabito
Aug 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M BalchJ F Thompson
Apr 16, 2002·The British Journal of Surgery·R S PrichardN J O'Higgins
Jan 10, 2003·The British Journal of Radiology·David W Townsend, Thomas Beyer
Feb 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Claus GarbeGernot Rassner
Feb 13, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Thomas BeyerStephan Mueller
Aug 22, 2003·Seminars in Nuclear Medicine·Paul E KinahanThomas Beyer
Sep 27, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·K HavengaTh Wobbes
Oct 11, 2003·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Catharina WongJohannes Czernin
Dec 25, 2003·JAMA : the Journal of the American Medical Association·Gerald AntochStefan G Ruehm
Feb 21, 2004·CA: a Cancer Journal for Clinicians·Ahmedin JemalUNKNOWN American Cancer Society
Sep 3, 2004·The New England Journal of Medicine·Hensin TsaoArthur J Sober
Oct 20, 2004·Seminars in Nuclear Medicine·Kent P Friedman, Richard L Wahl
Oct 30, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gerald AntochLutz S Freudenberg

❮ Previous
Next ❯

Citations

Feb 14, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Felix M MottaghySven N Reske
Mar 29, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Klaus StrobelHans C Steinert
May 7, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Klaus StrobelV Kalff
Jan 22, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Patrick Veit-HaibachGerald Antoch
Jul 8, 2010·Journal of Gastrointestinal Cancer·Shirley SundersinghKathiresan Narayanaswamy
Aug 28, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A MaldonadoJ M Sierra
Jul 28, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P MohrA Buzaid
Nov 18, 2010·Journal of the National Cancer Institute·Yan XingJanice N Cormier
Feb 28, 2007·Nuclear Medicine Communications·Matthew S FalkBenjamin Franc
Dec 20, 2007·Nuclear Medicine Communications·Michael S HofmanUNKNOWN Melanoma Group
Sep 5, 2008·Nuclear Medicine Communications·Ivan A Ho ShonJohn F Thompson
Sep 22, 2010·Nuclear Medicine Communications·Elba C S Camargo EtchebehereEdwaldo E Camargo
Jan 9, 2007·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·D Michael King
Nov 23, 2006·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Rodney J HicksEddie W F Lau
Sep 26, 2012·Onkologie·Qin Li, Jigang Yang
Jan 29, 2009·World Journal of Surgical Oncology·Stephen P PovoskiEdward W Martin
Aug 8, 2008·Future Oncology·Rajmohan MuraliRichard A Scolyer
Aug 24, 2013·Nuklearmedizin. Nuclear Medicine·H A WiederJ Nagarajah
Aug 22, 2007·Radiology·Martin S JudenhoferBernd J Pichler
Aug 6, 2014·Case Reports in Gastrointestinal Medicine·Preethi ReddyBianca Afonso
May 27, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Bruno KrugThierry Vander Borght
Jan 7, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Thomas PflugerMayo Weiss
Mar 1, 2014·International Journal of Surgery·K PatelT Ismail
Jun 6, 2014·The British Journal of Radiology·G MurphyU Metser
Jun 30, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·S K HaerleD Holzmann
Jan 1, 2013·Current Radiology Reports·Johannes CzerninKen Herrmann
Jul 24, 2012·Current Problems in Diagnostic Radiology·Brian C AllenJacobo S Kirsch
Apr 25, 2012·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Georgios OrfaniotisMark Butterworth
Jan 1, 2011·PET Clinics·Imene ZerizerAdil Al-Nahhas
Jan 1, 2011·PET Clinics·Sergi Vidal-SicartFrancesca Pons
Jan 1, 2011·PET Clinics·Elif HindiéCéleste Lebbé
Jan 25, 2011·Journal of the American Academy of Dermatology·Wynnis L TomSheila Fallon Friedlander

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Christina PfannenbergHeinz P Schlemmer
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Christian Müller-HorvatHeinz-Peter Schlemmer
Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
A IagaruI R McDougall
© 2021 Meta ULC. All rights reserved