Diagnostic pitfalls in the evaluation of fine needle aspiration cytology of the thyroid: correlation with histopathology in 260 cases

Cytopathology : Official Journal of the British Society for Clinical Cytology
A N HaberalB Bilezikçi

Abstract

Fine needle aspiration cytology (FNAC) of the thyroid is a non-invasive, cost-effective screening procedure that is valuable for distinguishing neoplastic lesions from non-neoplastic nodules. The aim of this study was to determine the diagnostic accuracy of FNACs performed at our institution by correlating FNAC results with histopathological diagnoses. Two hundred and seventy-one aspiration cytology specimens followed by thyroidectomy were included in the study, and the results of 260 adequate FNACs were compared with their histological diagnoses. The sensitivity and specificity of thyroid FNAC for detecting neoplasia were 92.6% and 91.6%, respectively. There were 15 (5.7%) false positives and six (2.3%) false negatives. The results showed that follicular cells that exhibit some of the features of papillary carcinoma could be observed in a cytology slide of Hashimoto's thyroiditis, leading to a diagnostic pitfall. In addition, cellularity and overlapping cytological criteria in hyperplasia might lead to a false diagnosis.

References

Feb 1, 1996·Diagnostic Cytopathology·H J CarsonP Gattuso
Jun 1, 1997·Diagnostic Cytopathology·G K NguyenR R Villanueva
Mar 22, 2001·Archives of Pathology & Laboratory Medicine·M AmrikachiT M Wheeler
Mar 11, 2004·Thyroid : Official Journal of the American Thyroid Association·Lourdes R YlaganLouis P Dehner

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Citations

May 7, 2011·Endocrine Pathology·Frederico Fernandes Ribeiro MaiaDenise E Zantut-Wittmann
Aug 12, 2010·Indian Journal of Pathology & Microbiology·Maheswari EkambaramSurendra Kumar
Apr 3, 2013·Archives of Pathology & Laboratory Medicine·Robert L SchmidtLester J Layfield
Jul 23, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Zubair W Baloch, Virginia A LiVolsi
Feb 3, 2012·ANZ Journal of Surgery·Marc A SeifmanJonathan W Serpell
Jun 4, 2010·Cytopathology : Official Journal of the British Society for Clinical Cytology·S KaushalR Ray
Feb 27, 2013·Cytopathology : Official Journal of the British Society for Clinical Cytology·M TepeoğluS G Bayraktar
May 28, 2010·International Journal of Surgical Pathology·Fernando C Schmitt
Jul 25, 2012·International Journal of Oncology·Hideo NakajimaYoshiharu Motoo
Jun 23, 2016·Molecular and Clinical Oncology·Li-Qun DongPing Yu
Mar 18, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery

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