Diagnostic potential of dentatorubrothalamic tract analysis in progressive supranuclear palsy

Parkinsonism & Related Disorders
Morinobu SekiChristoph Scherfler

Abstract

The differentiation of progressive supranuclear palsy-parkinsonism (PSP-P) from Parkinson's disease (PD) remains a major clinical challenge. To evaluate the diagnostic potential of observer-independent assessments of microstructural integrity within infratentorial brain regions to differentiate PSP-Richardson's syndrome (PSP-RS), PSP-P and PD. 3T MRI parameters of mean diffusivity, fractional anisotropy, grey and white matter volumes from patients with PSP-RS (n = 12), PSP-P (n = 12) and mean disease duration of 2.4 ± 1.7 years were compared with PD patients (n = 20) and healthy controls (n = 23) by using statistical parametric mapping and the spatially unbiased infratentorial template. Subsequently MRI measurements of the dentatorubrothalamic tract were determined observer-independently by a validated probabilistic infratentorial atlas. The impairment of gait and postural stability was evaluated by a sum-score derived from the Unified Parkinson Disease Rating Scale. Significant mean diffusivity increases, fractional anisotropy decreases and corresponding volume loss were localized in mesencephalic tegmentum, superior cerebellar peduncle, decussation of superior cerebellar peduncle and dentate nucleus in PSP-RS and PSP-P compar...Continue Reading

Citations

Nov 27, 2018·Human Brain Mapping·Salvatore NigroAldo Quattrone
Feb 25, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Salvatore NigroAldo Quattrone
Aug 28, 2019·Journal of Parkinson's Disease·Morinobu SekiChristoph Scherfler
Mar 13, 2021·Journal of Neurology·Jennifer L WhitwellKeith A Josephs
May 20, 2021·Current Opinion in Neurology·Lydia ChougarStéphane Lehéricy
Aug 25, 2021·Nature Reviews. Neurology·Maria StamelouGünter U Höglinger

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