Diagnostic power of the non-ischaemic forearm exercise test in detecting glycogenosis type V

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
J Y HogrelP Laforêt

Abstract

This was a retrospective study to assess the diagnostic value of the non-ischaemic forearm exercise test in detecting McArdle's disease. The study is a retrospective diagnostic study over 15 years (1999-2013) on a referred sample of patients suffering from exercise intolerance and various muscle complaints, generally with elevated creatine kinase (CK). In all, 1226 patients underwent the non-ischaemic forearm exercise test. Blood lactate, ammonia and CK levels were analyzed. DNA analyses and/or muscle biopsies were assessed to confirm the diagnosis of McArdle's disease. The results of 60 volunteers were used to compare with the results of study subjects. In this cohort, 40 patients were finally diagnosed with McArdle's disease. Absolute values of lactate and ammonia rise were used to discriminate all McArdle patients from healthy patients. A sensitivity and specificity of respectively 100% and 99.7% were calculated. The 24-h CK level showed no significant difference from the CK level at the day of the test and confirms the safety of the test. This study has formally assessed the diagnostic value of the non-ischaemic forearm exercise test in the detection of McArdle's disease. Very high sensitivity and specificity were observed....Continue Reading

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Citations

Nov 25, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A H V Schapira
Jan 20, 2018·Muscle & Nerve·Claudio SempliciniEmmanuel Fournier
Apr 13, 2017·Journal of Clinical Pathology·Jean-Yves HogrelPascal Laforet
Mar 29, 2019·Journal of Clinical Pathology·Jean-Yves HogrelAnthony Béhin
Jul 25, 2017·Current Opinion in Neurology·Pascal LaforêtJohn Vissing
May 12, 2018·Acta Neurologica Scandinavica·J-B NouryF Rannou
Nov 12, 2018·Acta neurologica Belgica·Paulo José LorenzoniRosana Herminia Scola
Aug 11, 2021·Experimental and Therapeutic Medicine·Ju-Hyung KangHaing-Woon Baik

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