PMID: 9545620Apr 18, 1998Paper

Diagnostic role of residual volume in paediatric patients with chronic symptoms of the lower airways

Clinical Physiology
M A Walamies

Abstract

In bronchial asthma, measurement of absolute lung volumes may reveal lung dysfunction more readily than forced expiratory spirometry. Sixty-one children (aged 4-16 years) with mild to moderate bronchial asthma and 35 children (aged 7-16 years) with other symptoms of the lower airways (OSLA) were studied, and the plethysmographic results were compared with data obtained from 36 healthy volunteers aged 6-16 years. In the first test session, repeatability of forced expiratory volume in one second (FEV1), forced vital capacity (FVC), residual volume (RV), functional residual capacity (FRC) and total lung capacity (TLC) were good. Control subjects were also tested the next day, and intra-subject variability of repeat pulmonary function testing was in the normal range. The FEV1/FVC ratio was significantly higher in control subjects than in patients with asthma or OSLA, but only the decrease in RV after bronchodilator challenge separated patients with asthma from patients with OSLA. Changes in FEV1 and RV after bronchodilator challenge had a significant, although low, inverse correlation. An increase of > or = 5% in FEV1 had a positive predictive value of 44% and a negative predictive value of 68% for the clinical diagnosis of bronchi...Continue Reading

References

Oct 1, 1987·The American Review of Respiratory Disease·M J KrowkaR E Hyatt
Feb 1, 1994·American Journal of Respiratory and Critical Care Medicine·P L EnrightD W Cockroft
Mar 1, 1965·The Journal of Pediatrics·W H TOOLEYJ A NADEL

Related Concepts

Asthma
Broncholytic Effect
Forced Expiratory Volume Function
Functional Residual Capacity
Plethysmography
Residual Volume
Respiratory Function Tests
Respiratory Tract Diseases
Spirometry
Total Lung Capacity

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.