PMID: 8947344Nov 1, 1996Paper

Diagnostic significance of in vitro T-cell proliferative responses to house-dust mite Der p 1 in children with dust-mite allergy

Allergy
G HorneffV Wahn

Abstract

The study aimed to investigate the possible diagnostic significance of T-cell proliferative responses to purified Der p 1 antigen in allergic children with and without allergic sensitization to house-dust-mite (HDM) allergens. T-cell reactivity to purified Der p 1 antigen was analyzed in 24 children with allergic sensitization to HDM demonstrated by RAST and/or positive skin prick tests. Twelve healthy young adults and 11 children with allergic sensitizations other than HDM served as controls. Of 25 HDM-allergic patients, 16 displayed strong T-cell reactivity to Der p 1 (stimulation indices > 3): nine patients showed no T-cell proliferation despite the presence of specific IgE, and five showed no responses despite positive skin prick test. In two patients, a weak T-cell response to Der p 1 could be demonstrated in the absence of specific IgE and negative skin test result. The two affected subjects did not show evidence of mite allergy. No T-cell responses were observed in adult controls (stimulation indices < 3). We conclude that the assessment of T-cell reactivity to Der p 1 is of little value for the diagnosis of HDM allergy. The importance of T-cell proliferative responses for the study of the pathogenesis of HDM allergy rem...Continue Reading

References

May 1, 1992·The Journal of Allergy and Clinical Immunology·R M O'BrienA M Wootton
Aug 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M T KasaianJ F Bond
Aug 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R M O'Brien, W R Thomas
Jul 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J W UphamP N Le Souef

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Citations

Oct 6, 2001·Veterinary Immunology and Immunopathology·T J NuttallP B Hill
Jun 10, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B J HalesW R Thomas

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