PMID: 3531214Jul 1, 1986Paper

Diagnostic significance of influenza subtype-specific IgG, IgA, and IgM antibodies

Journal of Biological Standardization
G DöllerH J Gerth


Up to now, the complement fixation test (CFT) has been the basis for the serological diagnosis of influenza virus infection in routine laboratories. Generally, low CF titers (1:20 or 1:40) are difficult to interpret. This means that the differentiation between recent and remote influenza infections is not possible by CFTs on single sera. Nonetheless this is generally possible by the subtype- and immunoglobulin class-specific immunofluorescence test (IFT) reported in this paper. Sera from 76 patients with confirmed influenza infection were tested and we obtained the following results: only 27.6% contained antibodies of all immunoglobulin classes, 51% contained IgG and IgA antibodies (without IgM) and 3.9% responded only with the IgG isotype. The IFT-positive and CFT-negative were 5.2% and the IFT-negative and CFT-positive 4%. In 7.9% no antibody rises were detected by CFT or by IFT despite virus isolation. Results from IFT may permit the interpretation of low CF titers. In contrast to CFT, IFT makes possible the differentiation between vaccinated and unvaccinated persons because vaccinated persons regularly produce IgM antibodies against all strains of the vaccine.


Feb 24, 1979·Lancet·K F Shortridge
Jan 1, 1979·Intervirology·F M Burnet
Jan 1, 1980·Journal of Immunological Methods·K N Masihi, W Lange
Apr 4, 1953·Lancet·A ISAACS


Oct 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P RautenbergU Ullmann
Apr 16, 1999·Journal of Virological Methods·P H RothbarthA D Osterhaus
Mar 1, 1989·Journal of Clinical Microbiology·T VikerforsJ T van der Logt

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