Diagnostic significance of pH, lactic acid dehydrogenase, lactate and glucose in pleural fluid

Respiration; International Review of Thoracic Diseases
B ChavalittamrongC Tuchinda


The pH, lactic acid dehydrogenase, lactate and glucose of pleural fluid simultaneous with serum lactic acid dehydrogenase, blood lactate and glucose were determined in 105 pediatric patients. The patients were classified into groups according to the diagnosis. The pleural fluid of empyema cases was found to have the lowest pH with a mean value of 6.83 (p less than 0.0075). The malignant pleural fluid has a relatively low pH with a mean value of 7.32. The lactic acid dehydrogenase in pleural fluid of empyema cases has the highest mean of 1,470.68 (p less than 0.05). The lactic acid dehydrogenase was found increased in malignancy, tuberculosis and parapneumonic effusion cases. Lactate level was found extremely high in empyema cases with a mean value of 13.68. It was also found extremely high in malignancy, tuberculosis and parapneumonic effusion cases. The glucose level was markedly decreased in empyema cases. There exists correlation of pleural fluid lactate to pH, lactic acid dehydrogenase and glucose, as well as that of pH to lactic acid dehydrogenase.


Dec 1, 1987·European Journal of Clinical Microbiology·A M JokipiiL Jokipii
Jun 23, 2009·Journal of Feline Medicine and Surgery·Andrea ZoiaDavid B Church
Jan 1, 1993·Postgraduate Medical Journal·N Berkman, M R Kramer
Jan 10, 2002·American Journal of Respiratory and Critical Care Medicine·John F HuntBenjamin Gaston
Oct 8, 2005·Respiration; International Review of Thoracic Diseases·Eduardo Garcia-PachonConrado Shum
Feb 14, 2012·Respiration; International Review of Thoracic Diseases·Mark BowlingRobert Chin
Apr 30, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·L J Burgess
Aug 27, 2005·European Journal of Pharmacology·Giovanna E CarpagnanoGiuseppe Valerio
Oct 2, 2017·Internal and Emergency Medicine·Giovanni PortaFernando Schiraldi
Sep 8, 2007·Journal of the American Animal Hospital Association·Daniel S Pang, Søren Boysen
Jan 1, 1988·Scandinavian Journal of Infectious Diseases·B Gästrin, A Lövestad
Apr 1, 1984·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·B BruunP Bartels

Related Concepts

Dengue Fever
Glucose Measurement
D-lactate Measurement
Glucose, (beta-D)-Isomer
Lactic Acid Measurement
Differential Diagnosis
Primary Malignant Neoplasm

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.