PMID: 7336189Jan 1, 1981Paper

Diagnostic significance of serum CK-MB elevations following surgical damage to skeletal muscles

Scandinavian Journal of Thoracic and Cardiovascular Surgery
R Bendz, S Ström

Abstract

Total creatine kinase (CK) and its isoenzyme MB (CK-MB) were studied in the serum of 14 patients following thoracotomy, mostly for pulmonary surgery, and in various thoracic muscles from another 9 patients subjected to the same procedure. CK-MB consistently appeared in the serum and was present in all muscle samples examined. CK-MB as a percentage of total CK (the CK-MB/CK ratio) was of similar order in serum and muscle, approximately 1.5%. Compared with previous findings after cardiopulmonary bypass surgery, maximum serum CK-MB activity occurred later, and the CK-MB levels as well as the CK-MB/CK ratio were considerably lower after non-cardiac thoracic surgery. It is suggested that the CK-MB/CK ratio 24 hours after operation may be used in the diagnosis of peri-operative myocardial infarction, particularly in non-cardiac surgery. After thoracotomy, this ratio was below 2.2%. In a series of patients with acute myocardial infarction, reported previously, the ratio was above 5.4%. Secondary rises of serum CK-MB following cardiac surgery should, apparently also be analysed in relation to the simultaneous total CK level.

References

Jan 1, 1979·Scandinavian Journal of Thoracic and Cardiovascular Surgery·S StrömS Lundberg
Jan 1, 1979·Scandinavian Journal of Thoracic and Cardiovascular Surgery·S StrömR Bendz
Nov 1, 1979·Annals of Clinical Biochemistry·S M LamplughT Deegan
Mar 1, 1977·Cardiovascular Research·E A OgunroJ P Shillingford
Sep 1, 1977·Annals of Clinical Biochemistry·J KrafftS B Rosalki
Oct 1, 1976·Journal of the Neurological Sciences·H SomerM Donner
Dec 1, 1976·Scandinavian Journal of Clinical and Laboratory Investigation
Jun 25, 1976·Deutsche medizinische Wochenschrift·W PrellwitzH P Schuster
Jan 1, 1980·Scandinavian Journal of Rheumatology·L E TrangO Mjös

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Citations

Mar 15, 1996·The American Journal of Cardiology·M MüllnerA N Laggner
May 9, 2006·The American Journal of Cardiology·Hendrik M NathoeUNKNOWN Octopus Study Group
Dec 12, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Hiromi UramotoYasunobu Okada
Jan 6, 1994·The New England Journal of Medicine·R M Smith, T S Neuman
Feb 1, 1983·Muscle & Nerve·A A Nanji
Sep 24, 2004·Circulation·Hendrik M NathoePeter P T de Jaegere
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·J A Lott, P W Landesman
Jan 1, 1984·Scandinavian Journal of Urology and Nephrology·S Ström
Jan 1, 1986·Langenbecks Archiv für Chirurgie·W Glinz, M Turina

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