Diagnostic Significance of Serum Levels of Nerve Growth Factor and Brain Derived Neurotrophic Factor in Diabetic Peripheral Neuropathy

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Qin SunLi-Li Tu

Abstract

BACKGROUND Our study aimed to explore the levels of nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) in healthy participants, type 2 diabetes mellitus (T2DM) patients, and diabetic peripheral neuropathy (DPN) patients in order to find their effects on DPN. MATERIAL AND METHODS The clinical data of 110 healthy participants (age: 57.3±8.2 year, height: 165.4±5.5 cm, weight: 64.1±7.5 kg), 83 T2DM patients (age: 56.5±7.9 year, height: 164.8±6.2 cm, and weight: 63.6±6.6 kg), and 65 DPN patients (age: 58.2±7.3 year, height: 166.7±6.7 cm, weight: 63.1±5.8 kg) were observed. ELISA was applied to detect serum NGF and BDNF levels. Receiver operating characteristic (ROC) curve analysis was performed to evaluate diagnostic value of serum NGF and BDNF levels in DPN. Logistic regression analysis was performed to analyze risk factors for DPN. RESULTS Serum NGF and BDNF levels decreased most in DPN patients. Subsequently, we determined that serum NGF and BDNF levels were correlated with: the course of disease for patients, fasting C-peptide (FCP), 2-hour postprandial C-peptide level (2-h PCP), glycosylated hemoglobin level (HbAlc), and 24-hour urinary microalbumin excretion (24-h UME). ROC curve analysis identified high s...Continue Reading

Citations

Feb 28, 2019·Addiction Biology·Giampiero FerragutiMauro Ceccanti
Feb 6, 2020·International Journal of Molecular Sciences·Olga RozanskaDorota Zozulinska-Ziolkiewicz
Jul 23, 2020·Memórias do Instituto Oswaldo Cruz·Maria Renata Sales NogueiraMaria Cristina Vidal Pessolani
Mar 7, 2021·International Journal of Molecular Sciences·Yoshikai FujitaAkihiro Nakamura
Aug 15, 2021·Journal of Diabetes and Its Complications·Panoraia BakaFrank Birklein

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Methods Mentioned

BETA
biosensor
ELISA

Software Mentioned

SPSS22

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