PMID: 8589804Jan 1, 1994Paper

Diagnostic significance of urinary enzymes for diabetes mellitus and hypertension

Enzyme & Protein
N IshiiT Saruta

Abstract

In order to evaluate tubular damage in diabetic patients, the activity of renal proximal tubule derived enzymes excreted in 24-hour urine were recorded in 5 groups as follows: (i) 48 noninsulin-independent diabetic patients with normal renal function and a urinary albumin excretion rate within the normal range; (ii) 45 noninsulin-dependent diabetic patients with normal renal function and a high urinary albumin level; (iii) 26 noninsulin-dependent diabetic patients with renal failure; (iv) 40 patients with essential hypertension and normal renal function, and (v) 48 normal control subjects. Regardless of whether cases were noninsulin-dependent diabetics with normal or high urinary albumin excretion rate or cases with renal dysfunction, urinary dipeptidyl aminopeptidase IV and N-acetyl-beta-D-glucosaminidase excretions were significantly higher than in healthy subjects, and urinary gamma-glutamyl transpeptidase excretion was significantly lower than in healthy subjects. No significant changes in urinary enzyme excretions showed specific variations in the essential hypertensive patients. These results suggest that there is tubular damage in the early stages of noninsulin-dependent diabetic patients with normal renal function and n...Continue Reading

Citations

Sep 25, 2014·Diabetes Care·Angelo Avogaro, Gian Paolo Fadini
Mar 12, 2010·Diabetes/metabolism Research and Reviews·Agnès MathesonBradley J Walsh
Dec 1, 2017·American Journal of Physiology. Renal Physiology·Yoshifumi KurosakiNaohito Ishii
Jan 20, 1998·Biochimica Et Biophysica Acta·D F Cunningham, B O'Connor
Jul 13, 1999·The Journal of Laboratory and Clinical Medicine·F PernerL Takács
Nov 1, 1996·Metabolism: Clinical and Experimental·N IshiiH Itoh

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