Diagnostic specificity of autoantibodies to M-type phospholipase A2 receptor (PLA2R) in differentiating idiopathic membranous nephropathy (IMN) from secondary forms and other glomerular diseases

Journal of Nephrology
A RadiceR A Sinico

Abstract

Autoantibody against phospholipase A2 receptor (anti-PLA2R) is a sensitive and specific biomarker of idiopathic membranous nephropathy (iMN), being found in approximately 70% of iMN patients and only occasionally in other glomerular diseases. However, whereas its diagnostic specificity vs. normal controls and other glomerulonephritides (GN) has been firmly established, its specificity vs. membranous nephropathy associated with various diseases (sMN) has given inconsistent results. The aim of our study was to evaluate the prevalence of anti-PLA2R antibodies in iMN in comparison with various control groups, including sMN. A total of 252 consecutive iMN patients, 184 pathological and 43 healthy controls were tested for anti-PLA2R antibody using indirect immunofluorescence (PLA2R IIFT, Euroimmun). Anti-PLA2R autoantibodies were detectable in 178/252 iMN patients, 1/80 primary GN, 0/72 secondary GN, 9/32 sMN and 0/43 healthy controls, with a diagnostic sensitivity of 70.6%. The diagnostic specificity of anti-PLA2R antibody vs. normal and pathological controls was 100 and 94.6% respectively. However, when the diagnostic specificity was calculated only vs. secondary forms of MN, it decreased considerably to 71.9%. Interestingly enough...Continue Reading

References

Jul 3, 2009·The New England Journal of Medicine·Laurence H BeckDavid J Salant
Dec 15, 2010·Seminars in Nephrology·Laurence H Beck
May 14, 2011·Journal of the American Society of Nephrology : JASN·Weisong QinZhihong Liu
Jun 3, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Elion HoxhaRolf A K Stahl
Dec 20, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Iva GunnarssonJohan Rönnelid
Aug 21, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Jean-François Cambier, Pierre Ronco
Dec 1, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Christopher P LarsenPatrick D Walker
Dec 12, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Barbora SvobodovaHanna Debiec
Apr 2, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Cornelia DähnrichWolfgang Schlumberger
Sep 12, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sjoerd A M E G TimmermansUNKNOWN Limburg Renal Registry
Nov 22, 2014·Clinical and Experimental Nephrology·Shin'ichi AkiyamaShoichi Maruyama
Mar 26, 2015·Journal of the American Society of Nephrology : JASN·Piero RuggenentiGiuseppe Remuzzi
Apr 4, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Thomas StehléHanna Debiec
Jun 20, 2015·American Journal of Nephrology·Qionghong XieChuan-Ming Hao
Sep 16, 2015·Nephrology·Prue A HillKaren M Dwyer
Oct 16, 2015·Clinical and Experimental Immunology·R A SinicoA Radice
May 18, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xin LiYurong Qiu
May 19, 2016·The New England Journal of Medicine·Elion HoxhaRolf A K Stahl
Nov 1, 2016·Journal of the American Society of Nephrology : JASN·An S De VrieseFernando C Fervenza
May 28, 2017·Clinical Journal of the American Society of Nephrology : CJASN·William G Couser

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Citations

Jun 12, 2020·Journal of Nephrology·Tian TaoZhangxue Hu
Mar 5, 2020·Auto- Immunity Highlights·Renato Tozzoli
Jan 12, 2021·Journal of Immunology Research·Zhaocheng DongBaoli Liu
Apr 4, 2021·Biomolecules·Yan GuDamu Tang
Nov 2, 2020·International Urology and Nephrology·Cícero de Oliveira Santos NetoGianna Mastroianni Kirsztajn
Apr 9, 2021·Frontiers in Immunology·Vladimir Tesar, Zdenka Hruskova
Apr 20, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Israel Nieto-GañánÁngela Carrasco-Sayalero
Apr 21, 2021·BMC Nephrology·Maryam ArghianiMahin Ghorban Sabbagh

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