Diagnostic surgical lung biopsies for suspected interstitial lung diseases: a retrospective study

The Annals of Thoracic Surgery
Martin I SigurdssonTomas Gudbjartsson

Abstract

Current guidelines for interstitial lung disease support a surgical biopsy for optimal diagnosis and treatment, yet only a minority of patients undergo such biopsy. Our objectives were to address the properties of a surgical lung biopsy for suspected interstitial lung disease, the diagnostic yield of the procedure, and whether it resulted in changes in diagnosis and treatment. A retrospective nationwide study including 73 patients (mean age, 57.3 years; 58% males) who underwent a surgical lung biopsy for suspected interstitial disease in Iceland between 1986 and 2007 was conducted. Patient records and histologic specimens were reviewed. Before the surgical biopsy a transbronchial or computed tomography-guided biopsy had been performed in two thirds of the patients. The complication rate for surgical lung biopsy was 16%, and 30-day operative mortality was 2.7%, both significantly higher in patients with preoperative respiratory failure. After the procedure, a definite histopathologic diagnosis was obtained in 81% of the patients. Usual interstitial pneumonia was the most common diagnosis (31%). The clinical diagnosis was changed for 73% of the patients, and in 53% of the patients the biopsy resulted in changes in treatment. Surg...Continue Reading

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Related Concepts

Needle Biopsy Procedure
Hospital Stay
Pain, Postoperative
Postoperative Procedures
Retrospective Studies
Severity of Illness Index
Surgical Procedures, Thoracoscopic
Incidence Studies
Survival Analysis
Hospital Mortality

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