Diagnostic surgical lung biopsies for suspected interstitial lung diseases: a retrospective study

The Annals of Thoracic Surgery
Martin I SigurdssonTomas Gudbjartsson


Current guidelines for interstitial lung disease support a surgical biopsy for optimal diagnosis and treatment, yet only a minority of patients undergo such biopsy. Our objectives were to address the properties of a surgical lung biopsy for suspected interstitial lung disease, the diagnostic yield of the procedure, and whether it resulted in changes in diagnosis and treatment. A retrospective nationwide study including 73 patients (mean age, 57.3 years; 58% males) who underwent a surgical lung biopsy for suspected interstitial disease in Iceland between 1986 and 2007 was conducted. Patient records and histologic specimens were reviewed. Before the surgical biopsy a transbronchial or computed tomography-guided biopsy had been performed in two thirds of the patients. The complication rate for surgical lung biopsy was 16%, and 30-day operative mortality was 2.7%, both significantly higher in patients with preoperative respiratory failure. After the procedure, a definite histopathologic diagnosis was obtained in 81% of the patients. Usual interstitial pneumonia was the most common diagnosis (31%). The clinical diagnosis was changed for 73% of the patients, and in 53% of the patients the biopsy resulted in changes in treatment. Surg...Continue Reading


Jul 21, 2001·American Journal of Respiratory and Critical Care Medicine·Gary HunninghakeM Millard
May 13, 2005·Chest·Christopher J LettieriAndrew F Shorr
May 28, 2005·The Annals of Thoracic Surgery·Michael E HalkosJoseph I Miller
Aug 13, 2005·Advances in Anatomic Pathology·Anthony A Gal
Apr 10, 2007·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Joo Hun ParkSeung Il Park


May 19, 2012·Interactive Cardiovascular and Thoracic Surgery·Juan J FiblaClaude Deschamps
Mar 19, 2014·Respiratory Medicine·Charlotte HyldgaardElisabeth Bendstrup
Jan 23, 2013·The Annals of Thoracic Surgery·Tomas Gudbjartsson
Nov 14, 2015·Respirology : Official Journal of the Asian Pacific Society of Respirology·Elizabeth A BelloliKevin R Flaherty
Dec 19, 2012·The Annals of Thoracic Surgery·Eugenio PompeoCesare Saltini
Jun 30, 2009·The Annals of Thoracic Surgery·Alex G Little
Jan 1, 2014·Thoracic Cancer·Tommaso C Mineo, Federico Tacconi
Apr 23, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Oren FruchterMordechai R Kramer
Sep 22, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Hulda R JonsdottirMagnus K Magnusson
Jun 30, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Annalisa CarlucciGianfranco Butera
Oct 15, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Nicola RotoloLorenzo Dominioni
Dec 10, 2015·American Journal of Respiratory and Critical Care Medicine·John P HutchinsonRichard B Hubbard
Aug 10, 2016·Chest·Nicholas J Pastis, Gerard A Silvestri
Sep 7, 2014·Asian Cardiovascular & Thoracic Annals·Joji SamejimaMunetaka Masuda
Mar 27, 2018·Pediatric Pulmonology·Caroline FortmannJens Dingemann
Apr 18, 2017·American Journal of Respiratory and Critical Care Medicine·Christopher J RyersonHarold R Collard
Aug 19, 2016·Asian Cardiovascular & Thoracic Annals·Mohammed KhalilMahmoud Loubani
Sep 1, 2018·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuAmerican Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and Latin American Thoracic Society
Apr 3, 2016·The European Respiratory Journal·Mark G JonesLuca Richeldi
Sep 24, 2016·The European Respiratory Journal·John P HutchinsonRichard B Hubbard
Jul 25, 2020·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuKevin C Wilson
Jul 12, 2012·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Bruno Guedes BaldiSuzana Pinheiro Pimenta
Mar 22, 2018·Journal of Bronchology & Interventional Pulmonology·Daniel A Culver, Jan C Grutters
Aug 28, 2018·Frontiers in Immunology·Ulrich BaumannStephen Jolles
Dec 7, 2018·Interactive Cardiovascular and Thoracic Surgery·Eugenio PompeoESTS awake thoracic surgery working group
Mar 7, 2020·Pediatric Allergy, Immunology, and Pulmonology·Ergun ErgunAydin Yagmurlu
Aug 16, 2016·QJM : Monthly Journal of the Association of Physicians·C SharpA R Medford
Oct 27, 2015·Journal of Bronchology & Interventional Pulmonology·Dante SchiavoFabien Maldonado
Feb 19, 2020·Regional Anesthesia and Pain Medicine·Chitaru KuriharaAnkit Bharat
Jan 13, 2021·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Masaaki NaganoSakashi Fujimori
Mar 2, 2021·ANZ Journal of Surgery·Aykut CilliNeslihan Akanil Fener
Apr 30, 2020·Seminars in Thoracic and Cardiovascular Surgery·Masahiro YanagiyaJun Nakajima
Aug 20, 2020·Diagnostic and Interventional Imaging·J BriouletO Morla

Related Concepts

Needle Biopsy Procedure
Hospital Stay
Pain, Postoperative
Postoperative Procedures
Retrospective Studies
Severity of Illness Index
Surgical Procedures, Thoracoscopic
Incidence Studies
Survival Analysis
Hospital Mortality

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Laryngeal Neoplasms

Laryngeal Neoplasms occur in the Larynx and are typically associated with smoking and alcohol consumption. Discover the latest research on Laryngeal Neoplasms here.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Related Papers

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Joo Hun ParkSeung Il Park
Seminars in Thoracic and Cardiovascular Surgery
Eugenio Pompeo
© 2021 Meta ULC. All rights reserved