Diagnostic test accuracy of ADC values for identification of clear cell renal cell carcinoma: systematic review and meta-analysis.

European Radiology
Mickael TordjmanStella K Kang

Abstract

To perform a systematic review on apparent diffusion coefficient (ADC) values of renal tumor subtypes and meta-analysis on the diagnostic performance of ADC for differentiation of localized clear cell renal cell carcinoma (ccRCC) from other renal tumor types. Medline, Embase, and the Cochrane Library databases were searched for studies published until May 1, 2019, that reported ADC values of renal tumors. Methodological quality was evaluated. For the meta-analysis on diagnostic test accuracy of ADC for differentiation of ccRCC from other renal lesions, we applied a bivariate random-effects model and compared two subgroups of ADC measurement with vs. without cystic and necrotic areas. We included 48 studies (2588 lesions) in the systematic review and 13 studies (1126 lesions) in the meta-analysis. There was no significant difference in ADC of renal parenchyma using b values of 0-800 vs. 0-1000 (p = 0.08). ADC measured on selected portions (sADC) excluding cystic and necrotic areas differed significantly from whole-lesion ADC (wADC) (p = 0.002). Compared to ccRCC, minimal-fat angiomyolipoma, papillary RCC, and chromophobe RCC showed significantly lower sADC while oncocytoma exhibited higher sADC. Summary estimates of sensitivity ...Continue Reading

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Citations

Jan 8, 2021·European Radiology·Nicolas F MichouxFrédéric E Lecouvet
Jan 14, 2021·Medicina·Carlos NicolauCarmen Sebastia
May 22, 2021·European Journal of Radiology·Athina C TsiliUNKNOWN Oncologic Imaging Subcommittee Working Group of the Hellenic Radiological Society
Oct 29, 2021·Acta Radiologica·Athina C TsiliMaria I Argyropoulou

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