Diagnostic test accuracy of antigenaemia assay for PCR-proven cytomegalovirus infection-systematic review and meta-analysis

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
H EguchiTakeshi Kaneko

Abstract

We aimed to assess diagnostic test accuracy of antigenaemia assay for PCR-proven cytomegalovirus (CMV) infection. We systematically searched studies that provide data both on sensitivity and specificity of the CMV antigenaemia assay using the PCR as the reference standard. Adults, children, infants, individuals who were immunocompromised for any reason, symptomatic patients and asymptomatic individuals were all included. A hierarchical summary receiver operating characteristics model was used for diagnostic meta-analysis. Study quality was assessed by Revised Tool for the Quality Assessment of Diagnostic Accuracy Studies. Protocol registration identification is CRD42016035892. We identified 75 eligible articles including 9058 CMV PCR-positive individuals and 22 232 PCR-negative individuals. The diagnostic odds ratio for positive antigenaemia was 30 (95% CI 24-38, I2 = 28%) and the area under the hierarchical summary receiver operating characteristic curve was 0.86 (95% CI 0.83-0.88). The summary estimates of sensitivity and specificity were 0.65 (95% CI 0.59-0.70) and 0.94 (95% CI 0.93-0.95), respectively. The positive likelihood ratio of 10.9 (95% CI 8.5-14.0) suggested that a positive result from the antigenaemia assay greatl...Continue Reading

References

Dec 29, 2004·The Annals of Thoracic Surgery·Catherine M Jones, Thanos Athanasiou
Jan 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jutta K PreiksaitisUpton Allen
Apr 27, 2005·Lancet·David A Grimes, Kenneth F Schulz
Dec 17, 2008·Annals of Internal Medicine·Mariska M G LeeflangUNKNOWN Cochrane Diagnostic Test Accuracy Working Group
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Sep 15, 2011·Nephrology·Helen PilmoreDavid Goodman
Oct 19, 2011·Annals of Internal Medicine·Penny F WhitingUNKNOWN QUADAS-2 Group
May 4, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Sara CantisánRafael Solana
Jul 31, 2013·Transplantation·Camille N KottonUNKNOWN Transplantation Society International CMV Consensus Group
Oct 9, 2013·Systematic Reviews·Mariska M G LeeflangPetra Macaskill
Nov 26, 2015·The Journal of Infectious Diseases·Sascha R EllingtonAthena P Kourtis

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Citations

Jul 25, 2019·Recent Patents on Biotechnology·Patrícia A F RibeiroAlexsandro S Galdino
Nov 7, 2021·European Journal of Clinical Investigation·Valentina PecoraroTommaso Trenti

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