Diagnostic tests: how to estimate the positive predictive value

Neuro-oncology Practice
Annette M Molinaro

Abstract

When a patient receives a positive test result from a diagnostic test they assume they have the disease. However, the positive predictive value (PPV), ie the probability that they have the disease given a positive test result, is rarely equal to one. To assist their patients, doctors must explain the chance that they do in fact have the disease. However, physicians frequently miscalculate the PPV as the sensitivity and/or misinterpret the PPV, which results in increased anxiety in patients and generates unnecessary tests and consultations. The reasons for this miscalculation as well as three ways to calculate the PPV are reviewed here.

References

Nov 2, 1978·The New England Journal of Medicine·W CasscellsT B Graboys
Sep 27, 2003·BMJ : British Medical Journal·Gerd Gigerenzer, Adrian Edwards
Oct 3, 2013·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Hendrik FriederichsAnne Weissenstein
Apr 24, 2014·JAMA Internal Medicine·Arjun K ManraiSachin H Jain

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Citations

Aug 9, 2020·The Journal of Infectious Diseases·Gerco den HartogRobert S van Binnendijk
Aug 29, 2020·Journal of Medical Virology·Ankit Kumar SahuKalpana Luthra
Feb 18, 2021·Future Microbiology·Ian GassiepPatrick N Harris
Nov 15, 2020·Scientific Reports·Guanglin TangDietmar Zechner
May 1, 2021·Journal of Clinical Medicine·Barbara Maria PiskórSławomir Ławicki
Aug 27, 2021·Journal of the International Neuropsychological Society : JINS·Katherine Y KoJody Kamminga
Sep 17, 2021·NPJ Digital Medicine·Bernhard KainzNicola Curry

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