Abstract
Snake venom toxins are invaluable for the assay of coagulation factors and for the study of haemostasis generally. Thrombin-like enzymes (SVTLE) are used for fibrinogen and fibrinogen breakdown product assays as well as detecting dysfibrinogenaemias. Since SVTLE are not inhibited by heparin, they can be used for assaying antithrombin III in samples containing heparin. Snake venom prothrombin activators are utilised in prothrombin assays, whilst Russell's viper venom (RVV) can be used to assay clotting factors V, VII, X and lupus anticoagulants (LA). Activators from the taipan, Australian brown snake and saw-scaled viper have also been used to assay LA. Protein C (PC) and activated PC (APC) resistance can be measured by means of RVV, Protac (from Southern copperhead snake venom) and STA-Staclot (from Crotalus viridis helleri) whilst von Willebrand factor can be studied with Botrocetin (Bothrops jararaca). Finally, snake venom C-type lectins and metalloproteinase disintegrins are being used to study platelet glycoprotein receptors and show great potential for use in the routine coagulation laboratory.
Citations
Oct 13, 2011·Archives of Toxicology·Nasit Igci, Duygu Ozel Demiralp
Jul 8, 2010·The Protein Journal·Frank Denis Torres-HuacoSergio Marangoni
May 12, 2004·Biochimie·Simone KashimaSuzelei C França
Nov 20, 2009·AIDS Research and Therapy·Ramachandran MeenakshisundaramPonniah Thirumalaikolundusubramanian
Oct 20, 2011·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Dayane L Naves de SouzaVeridiana M Rodrigues
Feb 27, 2010·Toxicon : Official Journal of the International Society on Toxinology·Júnia de O CostaFábio de Oliveira
Oct 27, 2009·Thrombosis Research·Holenarasipura V ShivaprasadBannikuppe S Vishwanath
Sep 2, 2008·Toxicon : Official Journal of the International Society on Toxinology·Adrijana LeonardiIgor Krizaj
Jan 12, 2008·Toxicon : Official Journal of the International Society on Toxinology·Carolina P BernardesFábio de Oliveira
Sep 18, 2012·International Journal of Laboratory Hematology·I MackieUNKNOWN British Committee for Standards in Haematology
Jul 13, 2004·Toxicon : Official Journal of the International Society on Toxinology·Maurício V MazziSuely V Sampaio
Apr 29, 2015·Journal of Biochemical and Molecular Toxicology·Kadi-Saci Amel, Laraba-Djebari Fatima
Jan 20, 2017·Scientific Reports·Cherine H KimJohn H Zhang
Sep 23, 2018·Journal of Neuroscience Research·Devin W McBrideJohn H Zhang
Mar 3, 2019·Toxins·Johannes A Eble
Jul 5, 2007·Molecular Pharmacology·Chun-Chieh HsuTur-Fu Huang
Aug 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·David Meléndez-MartínezCuauhtémoc Licona-Cassani
May 1, 2021·Biomedicines·Volker Herzig
May 7, 2021·JA Clinical Reports·Kaoru SuzukiShoichi Uezono
Sep 28, 2021·Journal of Medicinal Chemistry·Upasana PuzariAshis K Mukherjee