Diagnostic utility of 123I-BMIPP imaging in patients with Takotsubo cardiomyopathy
Abstract
Takotsubo cardiomyopathy is a cardiac syndrome with an acute onset defined by chest symptoms and ST segment elevation on electrocardiograms. Takotsubo cardiomyopathy is sometimes misdiagnosed as acute myocardial infarction (AMI). Therefore a non-invasive diagnostic method is needed to be established for setting up appropriate strategies. The purpose of this study was to detect myocardial metabolic abnormalities and to determine the diagnostic usefulness of (123)I-beta-methy-iodophenyl pentadecanoic acid ((123)I-BMIPP) imaging in patients with takotsubo cardiomyopathy. We examined 16 patients with takotsubo cardiomyopathy and 12 with AMI in the left anterior descending artery. All patients were studied with resting (123)I-BMIPP imaging. Total defect score (TDS) of (123)I-BMIPP and perfusion were semi-quantitatively determined with single-photon emission computed tomography (SPECT) imaging using a 17-segment 5-point model. TDS of (123)I-BMIPP were 4.8 ± 2.7 in patients with Takotsubo cardiomyopathy and 22.4 ± 10.7 in AMI. The ratio of summed BMIPP defect score of non-apical to apical segments in Takotsubo cardiomyopathy was smaller than that of the patients with AMI (0.1 ± 0.1 vs. 1.1 ± 0.7, p < 0.0001), indicating that (123)I-BM...Continue Reading
References
Assessment of coronary microcirculation in patients with takotsubo-like left ventricular dysfunction
Acute impairment of regional myocardial glucose uptake in the apical ballooning (takotsubo) syndrome
Citations
Diagnostic performance of hybrid cardiac SPECT/CT imaging for patients with takotsubo cardiomyopathy
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